复方苦参注射液联合化疗治疗局部晚期非小细胞肺癌的临床观察

Clinical Observation on Treatment of the Locally Advanced Non-small Cell Lung Cancer with Compound Kushen Injection and Chemotherapy

目的:观察复方苦参注射液联合化疗治疗局部晚期非小细胞肺癌的临床效果。方法:将60例明确诊断的局部晚期非小细胞肺癌随机分为观察组和对照组各30例,观察组采用GP方案联合复方苦参注射液,对照组采用PP方案,观察治疗效果和不良反应。结果:观察组短期有效率56.67%,对照组50.00%,比较无统计学意义(P>0.05);观察组短期临床受益率93.33%,对照组73.33%,比较具有统计学意义(P<0.05);观察组不良反应发生率和生活质量均好于对照组(P<0.05)。结论:复方苦参注射液联合GP方案治疗局部晚期非小细胞肺癌可提高总体临床受益率,明显降低化疗的不良反应,提高生活质量,值得临床推广应用。

Objective： To explore the clinical efficacy of treatment of locally advanced non-small-cell lung cancer with compound Kushen injection and chemotherapy.Method： Selected 60 patients with locally advanced non-small-cell lung cancer were divided into the intervention group（30 cases） and control group（30 cases）.Patients in intervention group were treated with GP program and compound Kushen injection;patients in control group were treated with TP program.Observed and compared the therapeutic effect and adverse reactions.Result： The short-term efficacy was 56.67% in intervention group and 50.00% in the control group,there was no significant difference between the two groups（P0.05）.Clinical benefit rate comparison： intervention group 93.33%,control group 73.33%,with statistically significant difference（P0.05）.The incidence of adverse reactions and quality of life in the intervention group were better than that of control group（P0.05）.Conclusion： The locally advanced non-small-cell lung cancer treatment of compound Kushen injection and chemotherapy could raise the clinical benefit rate and quality of life,and reduce adverse reaction,and hence is worthy of being recommended in clinical practice.