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急性冠脉综合征患者血清MCP-1水平与MCP-1基因-2518G/A多态性和相关因素的相关性 被引量：2

Association of the Serum MCP-1 Level with MCP-1 Gene-2518G/A Polymorphism and the Relevant Factors in Patients with Acute Coronary Syndrome
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摘要 目的探讨中国常州地区汉族人群急性冠脉综合征(ACS)患者血清单核细胞趋化蛋白-1(MCP-1)水平与MCP-1基因-2518G/A多态性和相关因素的相关性。方法对101例ACS患者(ACS组)和73例因胸闷(痛)住院经冠脉造影检查证实无冠脉病变者(对照组)用聚合酶链式反应限制性酶切片段长度多态性技术检测了MCP-1基因-2518G/A多态性,用ELISA方法检测了血清MCP-1水平。结果 MCP-1基因-2518 G/A位点的AA、GG和GA基因型及等位基因频率在ACS组和对照组间的差异均无统计学意义(均P>0.05);血清MCP-1水平(M/IQR)ACS组显著高于对照组(263.65/385.78 pg/ml vs 100.71/134.02 pg/ml,P<0.01);在ACS组和对照组的组内任何基因型之间,血清MCP-1水平(M/IQR)的差异均无统计学意义(均P>0.05);ACS组血清MCP-1水平(M/IQR)与年龄、糖尿病和吸烟成正相关,与男性成负相关,与高血压和高血脂无关。结论在中国常州地区汉族人群中,ACS和非冠心病患者的血清MCP-1水平与MCP-1基因-2518G/A多态性无关联,与某些冠心病易患因素相关。 Objective To investigate the association of serum monocyte chemoattractant protein-1（MCP-1） level with polymorphism in the MCP-1 gene-2518 G/A and the relevant factors in patients with acute coronary syndrome（ACS） in Chinese Han population of Changzhou region.Methods The polymorphism in the MCP-1 gene-2518 G/A was genotyped by PCR-RFLP and the serum MCP-1 level was measured by ELISA in 101 patients with ACS（ACS group） and 73 subjects（control group） with chest pain who were free from coronary heart disease tested by coronarography.Results No significant differences in the frequencies of the AA,GG and GA genotype and allele frequency of MCP-1 gene-2518 G/A locus were found between patients with ACS and subjects freed from coronary heart disease（all P0.05）.Serum MCP-1 level（M/IQR）in ACS group was significantly higher than that in the control group（263.65/385.78 pg/ml vs 100.71/134.02 pg/ml,P0.01）.No significant difference in serum MCP-1 level（M/IQR） was found among the any of the genotypes of MCP-1 gene-2518G/A in ACS group and the control group（all P0.05）.Serum MCP-1 level（M/IQR） was positively correlated with the age,diabetes and smoking,negatively correlated with the male,and unrelated with the hepertention and hyperlipidemia in ACS group.Conclusions Serum MCP-1 level in patients with ACS and subjects freed from coronary heart disease is irrelevant with the MCP-1 gene-2518G/A polymorphism and related to some risk factors of coronary heart disease in Chinese Han population of Changzhou region.
作者 何国平 姜九 师干伟 许联红 戚传平
机构地区 江苏大学附属武进医院心血管内科 江苏大学附属武进医院中心实验室
出处 《苏州大学学报（医学版）》 CAS 北大核心 2011年第5期776-780,共5页 Suzhou University Journal of Medical Science
基金 江苏大学临床医学科技发展基金资助项目(JLY20080065)
关键词 单核细胞趋化蛋白-1 急性冠脉综合征 基因多态性 monocyte chemoattractant protein-1 acute coronary syndrome gene polymorphism
分类号 R543.3 [医药卫生—心血管疾病]
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参考文献10

  • 1Libby P, Geng YJ, Aikawa M, et al. Macrophages and atherosclerotic plaque stability [ J ]. Curr Opin Lipidol, 1996,7(5) :330 - 335.
  • 2Arakelyan A, Petrkova J, Hermanova Z, et al. Serum le- vels of the MCP-1 chemokine in patients with ischemic stroke and myocardial infarction [ J ]. Mediators of Inflam- mation, 2005,3 (2005) : 175 - 179.
  • 3Bucova M, Lietava J, Mrazek F, et al. The MCP-1- 2518A/G single nucleotide polymorphism is associated with isehemic heart diaease and myocardial infarction in men in the Slovak population [ J ]. Bratisl Lek Listy,2009, 110(7) :385 -389.
  • 4师干伟,何国平,戚传平,高磊,戚猛,沈丹丹,钱志宏,许联红.MCP-1基因A-2518G多态性与不稳定性心绞痛关系的初步分析[J].江苏大学学报（医学版）,2009,19(6):523-526. 被引量：1
  • 5McDermott DH, Yang Q, Kathiresan S, et al. CCL2 poly- morphisms are associated with serum monocyte chemoat- tractant protein-1 levels and myocardial infarction in the Framingham Heart Study [ J ]. Circulation, 2005,112 ( 8 ) : 1113 - 1120.
  • 6Cermakova Z, Petrkova J, Arakelyan A, et al. The MCP- 1-2518 ( A to G) single nucleotide polymorphism is not as-sociated with myocardial infarction in the Czech population [ J ]. Int J Immunogenet, 2005,32 ( 5 ) :315 - 318.
  • 7Iwai N, Kajimoto K, Kokubo Y, et al. Assessment of ge- netic effects of polymorphisms in the MCP-1 gene on serum MCP-1 levels and myocardial infarction in Japanese [ J ]. Circ J,2006,70 (7) :805 - 809.
  • 8Zhong C, Luzhan Z, Genshan M, et al. Monocyte che- moattractant protein-1-2518 G/A polymorphism, plasma levels, and premature stable coronary artery disease [ J ]. Mol Biol Rep,2010,37( 1 ) :7 - 12.
  • 9de Lemos JA, Morrow DA. Sabatine MS, et al. Associa- tion between plasma levels of monocytc chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes [ J ]. Circulation, 2003,107 ( 5 ) : 690 - 695.
  • 10Penz P, Bucova M, Lietava J, et al. MCP-1 -2518 A/G gene polymorphism is associated with blood pressure in is- chemic heart disease asymptomatic subjects [ J ]. Bratisl Lek Listy,2010,111 (8) :420 - 425.

二级参考文献8

  • 1McDermott DH, Yang Q, Kathiresan S, et al. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study [ J ]. Circulation, 2005, 112(8) :1113 - 1120.
  • 2Rovin BH, Lu L, Saxena R. A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression [ J]. Biochem Biophys Res Commun, 1999, 259(2) :344 - 348.
  • 3Szalai C, Duba J, Prohaszka Z, et al. Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1-2518G/G genotype in CAD patients [ J ]. Atherosclerosis, 2001, 158 ( 1 ) : 233 - 239.
  • 4Cam SF,Sekuri C, Sagcan A, et al. Effect of monocyte chemoattractant protein-1 ( MCP-1 ) gene polymorphism in Turkish patients with premature coronary artery disease [J]. Scand J Clin Lab Invest, 2008, 68(8) :801 - 805.
  • 5Cermakova Z, Petrkova J, Arakelyan A, et al. The MCP- 1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population [J]. Int J Immunogenet, 2005, 32(5):315- 318.
  • 6Boyle JJ. Macrophage activation in atherosclerosis : Pathogenesis and pharmacology of plaque rupture [ J ]. Curr Vasc Pharmacol, 2005, 3 ( 1 ) :63 - 68.
  • 7Gonzalez-Quesada C, Frangogiannis NG. Monocyte chemoattractant protein-1/CCL2 as a biomarker in acute coronary syndromes [ J ]. Curt Atheroscler Rep, 2009, 11(2) :131 - 138.
  • 8de Lemos JA, Morrow DA, Sabatine MS, et al. Association between plasma levels of monocyte chemoat-tractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes [ J ]. Circulation, 2003, 107(5) : 690 -695.

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苏州大学学报（医学版）
2011年 第5期

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