腰大池持续引流加鞘内注射治疗颅脑创伤术后鲍氏不动杆菌颅内感染疗效分析

Efficacy of continuous lumbar cisterna drainage with intrathecal polymyxin injection on treatment of intracranial infection by Acinetobacter baumannii after craniocerebral trauma surgery

目的探讨腰大池持续引流加鞘内注射多黏菌素治疗鲍氏不动杆菌颅内感染的临床疗效。方法采用腰大池持续引流加鞘内注射多黏菌素治疗23例颅脑创伤术后鲍氏不动杆菌感染的患者,观察临床疗效。结果 23例鲍氏不动杆菌颅内感染患者,2例死于中枢系统衰竭,1例死于多脏器衰竭,1例患者治疗过程中自动出院;19例临床治愈,治愈率82.6%;19例治愈病例均随访1～6个月,无一例再次发生颅内感染。结论腰大池持续引流联合鞘内注射多黏菌素治疗鲍氏不动杆菌颅内感染是一种安全可行、疗效确切、并发症少的治疗方法。

OBJECTIVE To explore the treatment effect of continuous lumbar cisterna drainage and intrathecal colistin to intracranial infection of Acinetobacter baumannii. METHODS We cured 23 patients of intracranial infection of A.baumannii with the method of continuous lumbar cisterna drainage and intrathecal colistin. RESULTS In 23 patients of intracranial infection of A.baumannii,2 patients died of central failure,1 patient died of multiple organ failure and 1 patient require discharge in treatment.19 patients were clinical cured and the cure rate was 82.6%.19 clinical cured patients were followed-up for 1 to 6 months,none of them caught intracranial infection again. CONCLUSION The treatment of intracranial infection of A.baumannii by continuous lumbar cisterna drainage and intrathecal colistin is a safe and effective treatment and with less complications.