连栀矾溶液加锡类散保留灌肠治疗慢性溃疡性直肠炎疗效观察

Clinical efficacy of Lianzhifan solution plus Xileisan retention enema for chronic ulcerative proctitis

目的探讨连栀矾溶液加锡类散保留灌肠治疗慢性溃疡性直肠炎的临床疗效。方法 72例慢性溃疡性直肠炎患者随机分为治疗组和对照组,每组36例,治疗组采用连栀矾溶液加锡类散保留灌肠治疗,对照组采用口服柳氮磺吡啶片,庆大霉素、甲硝唑保留灌肠治疗。结果治疗组和对照组临床治愈率分别为61.11%和44.44%,总有效率分别为86.11%和75%,两组病例治疗后治愈率、总有效率比较差异有统计学意义(P<0.05)。治疗组在改善肛门坠胀感、黏液脓血便等主要临床症状方面优于对照组,差异有统计学意义(P<0.05)。结论连栀矾溶液加锡类散保留灌肠治疗慢性溃疡性直肠炎疗效显著,患者易于接受,值得临床推广应用。

Objective To observe the clinical efficacy of Lianzhifan solution plus Xileisan retention enema for chronic ulcerative proctitis. Methods 72 patients with chronic ulcerative proctitis patients were randomly divided into treatment group and control group （36 cases each group）, the treatment group were treated with Lianzhifan solution plus Xileisan retention enema, in the control group with oral sulfasalazine tablets, gentamicin, metronidazole retention enema. Results Clinical cure rates were 61.11% and 44.44%, the to- tal effective rates were 86.11% and 75 % in the treatment group and control group, respectively, and both have statistically significant difference （ P d0. 05 ）. The difference in improving the heavy feeling in the anus and mucus blood and pus and other major clinical symptoms, is also significant in two groups （ P 〈0.05）. Conclusion Lianzhifan solution plus Xileisan retention enema for chronic ulcerative proctitis significant effect, easily accepted by patients, is worthy of clinical application.