摘要
观察重组人纤维结合素多肽CH5 0对化疗小鼠巨噬细胞的影响。结果表明 ,腹腔连续注射CH5 0能防止化疗药物使外周血单核细胞数量和腹腔细胞的数量降低 ,能促进代谢活性、杀瘤活性、细胞因子分泌及脾淋巴细胞的增殖反应。提示CH5 0可提高肿瘤化疗药物的疗效。
The influence of CH50,a recombinant polypeptide of human fibronectin,on the function of macrophages of mice during chemotherapy was observed.The result showed that continuously intraperitoneal injection with CH50 could prevent the reduction of the amount of peripheral blood monocytes and peritoneal cells caused by chemotherapeutic agent,enhance metabolic activity,cytotoxicity,the secretion of cytokines,and the proliferation of splenic lymphocyte.It indicated that CH50 could improve the curative effect of chemotherapeutic agent.
出处
《中国生物制品学杂志》
CAS
CSCD
1999年第4期201-204,共4页
Chinese Journal of Biologicals
基金
国家自然科学基金!(No .3 9470 3 2 2 )
卫生部科学基金!(No.96 1 14 0 )资助