267例住院患者糖皮质激素应用调查分析

Investigation and Analysis on the Application of Glucocorticoid in 267 Cases

目的调查我院糖皮质激素类药物的应用状况,分析评价其用药合理性。方法回顾性调查我院2011年1月—3月使用糖皮质激素的住院患者病历资料267份进行统计分析。结果我院常见的糖皮质激素临床用途共9种,其中频率最高的为麻醉辅助用药,占调查病例数的57.30%;常用的糖皮质激素种类共8种,其中使用最多的为地塞米松注射液;疗程均在3月以内,其中<5 d的短疗程给药占77.53%;主要与阿司匹林、吲哚美辛、呋塞米、卡马西平、利福平存在配伍问题。结论我院糖皮质激素使用主要存在无指征用药、剂量疗程不规范、不良反应监测不及时等问题,须进一步加强监管。

OBJECTIVE To investigate the use of glucocorticoid in our hospital and evaluate its rationality. METHODS The medical records of 267 discharged cases administrated with glucocorticoid during January to March in 2011 were sampled for statistical analysis. RESULTS In our hospital, there were 9 types of clinical usage for glucocorticoid, in which the frequency as an anesthesia-assisted drug was the highest accounting for 57.30%. Eight glucocorticoids were used in clinic, the most used was dexamethasone injection. The courses of treatment of glucocorticoid were all within 3 months, and the short course within 5 days accounted for 77.53%. The incompatibility occurred between glucocorticoid and aspirin, indometacin, furosemide, carbamazepine and rifampicin. CONCLUSION The irrational use of glucocorticoid are serious in our hospital, thus management should be strengthened to ensure safe, effective and economic clinical drug use.