加味补阳还五汤对单纯型糖尿病视网膜病变患者血浆ET-1及NO的影响

Effect of Jiaweibuyanghuanwu decoction on plasma ET-1 and NO in nonproliferative diabetic retinopathy

目的:观察加味补阳还五汤治疗单纯型糖尿病视网膜病变(DR)的疗效及对患者血浆内皮素(ET-1)和一氧化氮(NO)的影响。方法:将70例患者随机分为两组各35例。两组均予以常规治疗,治疗组加服加味补阳还五汤,对照组口服多贝斯胶囊,疗程8周,观察两组治疗前后视力、眼底检查、眼底荧光血管造影及ET-1、NO等指标的变化。结果:治疗组总有效率优于对照组,有显著性差异(P<0.05)。治疗组治疗后ET-1明显下降、NO明显上升,与对照组比较,有显著性差异(P<0.05)。结论:加味补阳还五汤能有效改善患者血浆ET-1及NO水平,对单纯型DR具有较好的防治作用。

Objective：To explore the effect of Jiaweibuyanghuanwu decoction on plasma ET-1 and NO in nonproliferative diabetic retinopathy.Methods：70 nonproliferative diabetic retinopathy patients were randomly divided into treatment group and control group;treatment group was taken by Jiaweibuyanghuanwu decoction,and control group was taken by calcium dobesilate capsule.Vision,FFA and ET-1,NO were studied and compared between treatment group and control group.Results：The total effective rate of treatment group is superior to that of control group（P0.05）.Treatment group is superior to control group in descending ET-1 and ascending NO of nonproliferative diabetic retinopathy patients（P0.05）.Conclusion：Jiaweibuyanghuanwu decoction is efective in preventing and treating nonproliferative diabetic retinopathy.