摘要
以2-羟基-3-甲氧基苯甲醛为原料,通过烯丙基化反应制得3-甲氧基-2-(2-丙烯氧基)苯甲醛,然后经亚氯酸钠和氨基磺酸氧化得到3-甲氧基-2-(2-丙烯氧基)苯甲酸,再经过酯化、克莱森重排、氨解反应制得目标产物——阿利苯多,总收率为71.9%。部分中间体和目标化合物的结构经1HNMR、MS进行了表征。
The target compound--alibendol( I ) was prepared from 2-hydroxy-3-methoxybenzaldehyde via allylation, oxidation with NaCI02 and NH2SOzH, esterification, Claisen rearrangement and aminolysis reaction. The yield is 71.9% in the overall five steps. Some intermediates and the target product were identified by means of 1 HNMR and MS.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2011年第12期1199-1202,共4页
Fine Chemicals
基金
江西省科技计划项目(GJJ08072)
江西省教育厅科技项目~~