阿尔茨海默氏病与氧应激

Alzheimer's Disease and Oxidative Stress.

阿尔茨海默氏病（Ａｌｚｈｅｉｍｅｒ○ｓ ｄｉｓｅａｓｅ， ＡＤ） 是一种神经退行性疾病， 是老年人群痴呆最普遍的原因， 也是老年人病态和死亡的主要原因． 以阿尔茨海默氏病与氧应激为题， 从ＡＤ 发生的分子基础和氧应激基础， 以及β淀粉样蛋白（βａｍｙｌｏｉｄ ，βＡ） 的聚合作用和毒性与自由基的关系， 对近年来在ＡＤ 发生机制研究中引人注目的氧应激问题， 作一简要综述．

Alzheimers disease(AD) is a neurodegenerative disorder.It is the most common cause of dementia in aged population and also a main cause of death in aged people.The oxidative stress hypothesis of AD has focused on and described from four aspects :Molecular basis and oxidative stress basis of AD pathogenesis,and β amyloid aggregation and cytotoxicity related to reactive oxygen species.