重度联合免疫缺陷(SCID)小鼠性机能发育的初步研究

A Preliminary Study on Development of Sexual Function in SCID Mouse

本研究对ＳＣＩＤ小鼠与ＢＡＬＢ／ｃ小鼠的阴道开口时间、卵泡发育、精子发生及血浆促黄体素（ＬＨ）和睾酮（Ｔ）浓度进行了比较观察。结果表明．２种鼠阴道开口时间均为４０日龄．均在３０日龄时卵巢出现有腔卵泡。但ＳＣＩＤ雌鼠４５日龄有排卵．而同龄ＢＡＬＢ／Ｃ雌鼠未见排卵；ＳＣＩＤ雄鼠 ４０日龄附睾涂片有活精子． ＢＡＬＢ／Ｃ雄鼠 ４５日龄附睾涂片可见活精子。 ＳＣＩＤ小鼠初情期似乎有比ＢＡＬＢ／ｃ小鼠初情期略早的趋势。２种鼠血浆ＬＨ、Ｔ浓度没有显著差异。

We have made a comparison between SCID and BALB/c mouse in the time of virgina open. follicular development, spermatogenesis. and plasma levels of luteinizing hormone (LH) and testosterone (T) during and after sexual maturation. The results showed that the time of virgina open was 40 days of age and the first antral follicles appeared at 30 days of age in both of SCID and BALB/c mouse, However, SCID mouse ovulated during 40-45 days of age. In males. active spermatozoa were first seen in the slides from epididymas of 40-day-old SCID mouse and 45-day -old BALB/c mouse. It seemed that SCID mouse tends to reach puberty a little bit earlier than BALB/c mouse. The plasma levels of LH and T were not different between SCID and BALB/c mouse, both before and after sexual maturation.