温和灸治疗浅表性胃炎脾胃虚寒证的临床研究

Clinical observation on superficial gastritis of deficient cold of spleen and stomach type treated by mild moxibustion

目的:通过观察温和灸不同灸治时间治疗浅表性胃炎脾胃虚寒证患者的临床疗效和血清前列腺素E2(PGE2)、生长抑素(SS)、表皮生长因子(EGF)的变化,探讨艾灸温补效应的量效规律及对患者血清胃肠激素的调整作用。方法:将84例浅表性胃炎脾胃虚寒证患者随机分到温和灸20min组(A组)、温和灸40min组(B组)、药物组(C组)。观察3组治疗前后的PGE2、SS和EGF含量的变化及不同时点的临床疗效。结果:①3组治疗后比较,其疗效无显著性差异。1个月后随访时A组总有效率(100%)、B组总有效率(92.9%)均高于C组(67.9%)(P<0.05);②在浅表性胃炎症状积分方面,治疗后及治疗结束后1个月随访时,3组分别与治疗前比较均有显著性差异(P<0.01);治疗后3组间比较无显著性差异;治疗结束后1个月随访,A组低于C组有显著性差异(P<0.01)。③治疗后,3组血清PGE2含量均明显升高,与各组治疗前比较都具有显著性差异(P<0.05,P<0.01);B组血清EGF含量明显升高,与治疗前比较具有显著性差异(P<0.05)。结论:3种治疗方法均有明显疗效,且在远期疗效上,灸法组明显优于药物组,温和灸20min组及40min组疗效相当,灸法可能通过调节胃肠激素来治疗浅表性胃炎脾胃虚寒证。

Objective： Through observing the clinical effect and the content of the PGE2,SS,EGF of the serum caused by the treatment of different moxibustion time of the superficial gastritis Patients due to the spleen and stomach weakness,to investigate the regulation of the dose-effect relation and the adjustment function on gastrointestinal hormone of serum of patients caused by the mild and nourish effect with moxibustion.Methods： Eighty-four superficial gastritis Patients due to the spleen and stomach weakness were divided into mild moxibustion for twenty minutes,mild moxibustion for forty minutes and drug groups.To observe the changes of the content of the Prostaglandin E2（PGE2）,Somatostatin（SS） and Epidermal growth factor（EGF） before and after treatment between 3 groups and the clinical effect in different time.Results： ①The 3 groups were compared after treatment,their clinical effect have not significant difference.The total effective rates in A group（100%）,B group（92.9%） were higher than that in C group（67.9%） significantly（P0.05）.②Compared with before treatment,the superficial gastritis symptom score has a significant difference after treatment and during the 1 month follow-up（P0.01）;the superficial gastritis symptom score were compared after treatment has no significant difference;the superficial gastritis symptom score were compared during the 1 month follow-up,The A and B groups have no significant difference;Compared with the C group,the A group has a significant difference（P0.01）.③After treatment,the content of the PGE2 of the serum was increased obviously,compared with before treatment,there was a significant difference in each group（P0.05,P0.01）;After mild moxibustion for forty minutes,the content of the EGF of the serum in the B group was increased obviously,compared with before treatment,there was a significant difference（P0.05,P0.01）.Conclusions： All of the three treatment methods have curative effect,and the moxibustion groups were markedly higher than the drug group in long-term result.The mild moxibustion for twenty minutes group has the same effect as the mild moxibustion for forty minutes group.And the moxibustion may adjust gastrointestinal hormone to cure the superficial gastritis Patients due to the spleen and stomach weakness.