丙戊酸钠个体化剂量预防复杂热性惊厥复发的研究

The Controlled Study of Preventing Relapse of Complex Febrile Convulsion Children by Valproic Acid Individuate Treatment

目的:通过对照研究的方法,探讨丙戊酸钠个体化治疗预防复杂热性惊厥复发的优越性。方法:将我院神经内科新诊断为复杂热性惊厥并愿服用丙戊酸钠治疗的患儿随机分为2组,其中实验组进行个体化剂量治疗,对照组使用经验性用药治疗,2组进行对照研究。结果:丙戊酸钠个体化给药预防热性惊厥复发达稳态时的血药浓度低;个体化治疗用药剂量较经验用药小,但可取得相同疗效。相同剂量给药,则不同个体达稳态血药浓度不同。结论:丙戊酸钠在小儿体内代谢中个体差异大,因而提倡丙戊酸钠在预防复杂热性惊厥复发时遵循个体化治疗的原则,从小剂量开始使用,并在药物浓度的监测下进行个体化治疗。

Objective：TO explore the superiority of preventing relapse of complex febrile convulsion children by valproic acid（VPA） individuate treatment through the controlled study.Methods：Children with complex febrile convulsion and only use VPA in our neurological department were randomly divided into two groups,the experimental group for individual dose treatment,and the control group use experience administration treatment.Results：The blood concentration at steady-state of VPA individual treatment is low.The dosage of individuate treatment is less than experience,but can achieve the same effect.Different individual of steady blood drug concentration is different.Conclusion：Advocate the individual treatment,small doses begin to use and blood drug concentration monitoring as the VPA in children metabolism varied widely between individuals.