多沙唑嗪联合非那雄胺治疗良性前列腺增生观察

Observation of Finasteride and Doxazosin in Treatment of Men with Benign Prostatic Hyperplasia

目的:研究非那雄胺联合多沙唑嗪治疗良性前列腺增生(BPH)的疗效。方法:将前列腺体积>30 mL、国际前列腺症状评分(IPSS)>15分的良性前列腺增生80例随机分为A和B2组,2组均给予非那雄胺5 mg/d及多沙唑嗪4 mg/d联合治疗。A组3月后停用多沙唑嗪,B组6月后停用多沙唑嗪。2组在停用多沙唑嗪后均继续服用非那雄胺。于停用后1月评估最大尿流率、IPSS,超声测量残余尿。结果:A组IPSS评分、残余尿量和最大尿流率在治疗4月时与治疗前对比有显著性差异(P<0.05),治疗7月时与治疗4月时对比无显著性差异(P>0.05)。B组IPSS、残余尿量和最大尿流率在治疗4月时与治疗前对比有显著性差异(P<0.05),治疗7月时与治疗4月时对比无显著性差异(P>0.05)。A组与B组比较在治疗各时段IPSS、残余尿量和最大尿流率对比无显著性差异(P>0.05)。结论:对前列腺体积中度增大并合并下尿路症状(LUTS)的BPH患者,可以先予非那雄胺和多沙唑嗪联合治疗3月,待非那雄胺起效后即可停用多沙唑嗪,停用后仍能维持满意疗效。

Objective：To determine the effect of receiving combination of doxazosin and finasteride in treatment of men with lower urinary tract symptoms and with enlarged prostates.Methods：80 patients with a prostate size over 30 g and international prostate symptom score over 15 were divided A and B groups.A group with finasteride 5 mg daily and doxazosin 4 mg 3 months;B groups with finasteride 5 mg daily and doxazosin 4 mg 6 months.Evaluated the changes of IPSS,Qmax,post-void residual volume 1 month after stopping doxazosin.Results：In both group A and B,IPSS,Qmax and post-void residual volume improved significantly in 4 months（P〈0.05）,then,there was no more significantly changes in 7 months（P〈0 .05）.And compared group A and B,there was no significantly changes in IPSS,Qmax and post-void residual volume.Conclusion：Patients with lower urinary tract symptoms and moderately enlarged prostates initially receiving combination therapy with finasteride and an alpha-blocker for 3 months are likely to experience no significant symptom of deterioration after stopping doxazosin.