日本血吸虫虫卵肉芽肿与肝纤维化关系的研究

STUDIES ON THE RELATIONSHIP BETWEEN GRANULOMA AND HEPATIC FIBROSIS IN THE INFECTION OF SCHISTOSOMA JAPONICUM

目的从形态学角度来探讨日本血吸虫虫卵肉芽肿与肝纤维化之间的关系。方法用日本血吸虫尾蚴感染新西兰兔，观察虫卵肉芽肿大小、肝纤维化程度的动态变化，同时观察激活的肝星状细胞即肌成纤维细胞。结果感染后第4周α－SMA阳性细胞有表达（分级计分为1．13±0．33），第6周出现虫卵肉芽肿（大小为129±55，单位：103μm2，下同），在感染后第8周达高峰（202±86），肉芽肿周围开始出现成纤维细胞，其后随时间的推移肉芽肿逐渐缩小，而肝纤维化程度逐渐加重，α－SMA阳性细胞表达也逐渐增加。结论提示肉芽肿与肝纤维化无直接关系，而是间接延伸，其中肝星状细胞起重要的桥梁作用。

Objective To study the relationship between granuloma and hepatic fibrosis in the infection of Schistosoma japonicum. Methods New Zealand rabbits were used for the infection of (80±1) S. j cercariae and then, the areas of granuloma, the degree of hepatic fibrosis and the myofibroblast were observed. Results The granuloma appeared in the 6th week after infection and its areas reached biggest in the 8th week, then the granuloma shrank gradually but the degree of hepatic fibrosis aggravated gradually. Conclusions The myofiboblast is the key cell during the for mation and development of schistosomal hepatic fibrosis.