原子转移自由基聚合在生物材料中的应用

Atom Transfer Radical Polymerization for Biomaterials Applications

生物材料表面改性以及具有特定结构与功能的先进生物材料的合成始终是生物材料研究的核心课题。原子转移自由基聚合(ATRP)是一种新型自由基聚合,在生物材料表面改性以及新型生物材料合成方面具有巨大的应用前景。利用ATRP技术可以提高生物材料表面生物相容性、生物适应性以及生物功能性,如提高材料表面的抗生物污染性、血液相容性、细胞相容性以及抗菌性能等;同时,ATRP也可用于合成新型生物医用高分子材料,如两亲性高分子、纳米胶束、智能水凝胶以及一些具有特殊结构的高分子(包括星型、超支化、梳型高分子等)。ATRP技术与点击化学结合,可形成新的生物活性表面或者合成新的生物材料,可望产生更多的功能化的材料表面与生物材料。

Surface modification of biomaterials and synthesis of the advanced biomaterials with defined structure and function are always the central issues of biomaterials. Atom transfer radical polymerization （ATRP）, which is a kind of novel radical polymerization, has potential applications in biomaterials field. It can be used to improve surface biocompatibility, bio-adaptability and biofunctionability, such as improvement of anti-biofouling, blood compatibility, cell biocompatihility and antibacterial activity of biomaterials surfaces, etc. ATRP can be utilized to synthesize novel biomaterials such as amphiphilic polymer, nano micelle, smart hydrogel and polymer with special structure （including star polymer, hyperbranched polymer, comb polymer, etc）. Combination of click chemistry and ATRP, new bioactive surfaces and novel biomaterials will be produced.