体外受精-胚胎移植治疗不孕症临床分析

Clinical analysis of in vitro fertilization and embryo transfer in the treatment of infertility

目的 总结与探讨影响常规体外受精－ 胚胎移植（ＩＶＦ－ ＥＴ） 妊娠率的因素。方法 对１９９９ 年１ 月至８ 月在我院门诊接受ＩＶＦ－ ＥＴ的３６ 对不孕夫妇采用促性腺激素释放激素（ＧｎＲＨａ）／ 高纯促卵泡素（ＦＳＨＨＰ）／绒毛膜促性腺激素（ｈＣＧ） 刺激排卵方案，Ｂ 超监测卵泡发育情况并引导经阴道取卵，培养后加入丈夫精子孵育，将高质量胚胎转移至子宫。结果 取卵３５６ 个，平均每周期取卵１０ ．２ 个；受精率６６ ．５ ％ ；卵裂率８８．９％ 。移植胚胎１０８ 个，平均每周期移植３ ．３７ 个。结论 １２ 例妊娠，其中１０ 例临床妊娠，２ 例生化妊娠。开始周期妊娠率３２ ．４ ％ ，卵回收周期妊娠率３６．４％ ，移植周期妊娠率３７．５％ 。不孕年龄、不孕年限、不孕原因、胚胎质量是影响妊娠率的因素。

Objective To summarize and to evaluate the clinical efficacy of conventional in vitro fertilization and embryo transfer (IVF-ET) procedures in the treatment of infertility couples.Methods Thirty six infertility couples underwent conventional IVF ET procedures from January 1999 to August 1999 .Follicular stimulations by GnRH a/FSH HP/hCG were carried out.Ovarian response and Oocyte retrieval was assessed and guided by B modal utrasound.After 4～6 hours incubation of oocytes,husband's sperm were added. High quality embryos were transferred into uterine cavity.Results The main data are as follows:Total number of 356 oocyte retrievals with an average of 10.2 per cycle;fertilization rate 66.5%;cleavage rate 88.9%;The number of embryos transferred is 108 with an average of 3.37 per cycle.Conclusions Twelve cases are pregnancy,of which 10 cases with clinical pregnancy and 2 cases with biochemical pregnancy.Cycle initiated pregnancy rate is 32.4%;Oocyte retrieval cycle pregnancy rate is 36.4% and transfer cycle pregnancy rate is 37.5%.Infertility age,infertility duration,cause of infertility and quality of embryo are the factors affecting the pregnancy rate.