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正链RNA病毒复制酶结构与功能研究进展 被引量：3

REVIEW: STRUCTURE AND FUNCTIONS OF RNA-DEPENDENT RNA POLYMERASE OF POSITIVE-STRAND RNA VIRUSES
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摘要 正链RNA病毒是家族非常庞大,可以感染多种动、植物及人的一类病毒。研究这类病毒的复制机理和调控方式对于阐明病毒的致病机制,以及研制新型抗病毒药物和疫苗等具有重要意义。RNA依赖性RNA聚合酶(RNA-dependent RNA polymerase,RdRp)是正链RNA病毒进行复制的关键蛋白酶,研究其结构与功能是了解病毒复制机理的前提和基础。本文即对近年来关于正链RNA病毒RdRp的结构与功能研究进展情况进行综述。 The positive-strand RNA viruses are composed of a large family that infect various animals,plants and human beings.Understanding on the replication and regulation mechanisms of RNA viruses is important to investigate pathogenesis and develop antiviral drugs and vaccines.The RNA-dependent RNA polymerase（RdRp） is a key enzyme responsible for the replication of positive-strand RNA viruses.This review focused on recent progress in research on structure and functions of RdRp.
作者 王超 吴润 刘光清
机构地区 中国农业科学院上海兽医研究所 甘肃农业大学动物医学院
出处 《中国动物传染病学报》 CAS 2011年第5期76-82,共7页 Chinese Journal of Animal Infectious Diseases
基金 公益性行业(农业)科研专项(201003012) "863"计划课题(2011AA10A200)
关键词 正链RNA病毒 RNA依赖性RNA聚合酶 结构 功能 Positive-strand RNA virus RNA-dependent RNA polymerase（RdRp） structure function
分类号 S852.659.6 [农业科学—基础兽医学]
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参考文献39

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共引文献3

同被引文献40

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  • 3刘家森,陈淑红,刘怀然,孟庆文,庞海,孔宪刚.SARS冠状病毒复制酶蛋白nsp8的原核表达[J].中国生物工程杂志,2005,25(9):55-58. 被引量：2
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引证文献3

二级引证文献7

中国动物传染病学报
2011年 第5期

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