高血压病患者治疗前后的血浆NPY含量变化及临床意义

Clinical Significance of Measuring Plasmic Neuropeptide-Y in Patients with Hypertension before and after Benalapril Treatment

对 8 2例高血压病 ( EH)患者测定苯那普利治疗前后的血浆 NPY含量 ,并与 5 8例健康人作对照。结果 :EH患者血浆 NPY含量与正常对照组存在非常显著性差异 ( P<0 .0 1) ,EH分期、高血压程度与血浆 NPY含量呈正相关关系。苯那普利治疗 8周时 ,EH患者血浆 NPY含量显著下降 ,NPY浓度与血压下降幅度呈密切相关 ( r=0 .70 2 3,P<0 .0 1)。提示 NPY参与了高血压病的发生 ,苯那普利可通过降低 NPY途径起到降压作用。

The plasmic neuropeptide Y(NPY)were measured in 58 normal controls and 82 hypertension before and after of Benalapril treatment Results:There were significant difference of plasmic NPY between hypertension and normal controls (p<0 01) Hypertension were significantly correlated with plasmic NPY After 8 weeks′ treatment with Benalapril,NPY decreased significantly in hypertension The plasmic NPY level was also related to blood pressure(r=0 7023,p<0 01) The suggest that NPY participated in the pathogenesis of hypertension Benalapril could decrease blood pressure by decreasing NPY