新疆维吾尔自治区部分县市健康人群麻疹抗体水平监测

Surveillance on Measles Antibody Levelin Healthy Population in Partial Counties and City of Xin jiang Uygur Autonomous Region

为了解新疆维吾尔自治区部分县市健康人群麻疹抗体水平，在１９９７ 年１０ 月至１９９８ 年１０ 月间，采用多阶段抽样方法，对哈密地区和巴音部郭楞蒙自治洲博湖县的６１７ 名０～３９ 岁的健康人群进行了调查。结果显示：博湖县和哈密地区麻疹抗体阳性率分别为９２．９％ 和８９．３％ ，抗体滴度≥１∶８００ 的比例分别为６４．６％ 和５８．９％ ，但抗体几何平均滴度（ＧＭＴ）低于１９９０ 年全疆平均水平。这可能与近几年基础免疫和加强免疫工作质量有下降、麻疹疫苗免疫持久性下降有关。＜１ 岁组和１ 岁组麻疹抗体水平有显著性差异（χ２＝ ９．９６ ，Ｐ＜０ ．０５）；而１～９ 岁各年龄组间抗体水平无显著性差异。人群抗体滴度≥１∶８００ 的比例为６１．８％ 。根据此次调查可以预测两地区易感人群主要为０～１５ 岁儿童，应有针对性的制定有效的免疫对策，结合流行病学资料，及时发现并保护易感人群，达到控制麻疹的目的。

Inordertoknow the measlesantibodylevelin healthy populationin partialcountiesand Cityof Xinjiang Uygur Autonomousregion,wecarried outin Oct.1997to Oct.1998 aninvestigation into 617 healthy population of0～39 yearsoldin NamiPrefecture(includingtwocountiesandonecity there) and Bohu county with the method of multi-stage clustersampling. The resultsshowed that the measlesantibody positiverates were92.9% and89.3% ,theantibodytiters(≥1∶800) were64. 8% and 58.9% in Bohu county and Hami Prefecture respectively,butthe GMTwaslowerthan the yearly averagelevelof1990 of1990 of Xinjiang.This might beattributed partlytothequality ofser vicein basicandsupplementalimmunizationinrecentyearsand partlytovariationof measlesvirusand the declining ofim mune persistence of measles vaccine. There wasa significant differencein measles antibodylevelbetween 0yearold and 1 yearold groupsofchildren but no differenceamong 1 ～9 year old groups.Theantibodytiter(≥1∶800) ofthe populationsurveyed was61.8% .Accordingtothese data,it might be predicatedthatin theareassurveyedthe measlessusceptible population were mainly children of0～15 yearsold.So,considering with measlesepidemiologicaldata,weshould makeoutan effectiveim munestrategy to discover and protect earlierthe measlessusceptible persons,thusto ap proach the goalof measlescontrol.