垂体后叶素在门脉高压性胃病胃粘膜灌注中的作用

Effects of Vasopressin on Gastric Mucosal Perfusion in Rats with Portal Hypertensive Gastropathy

部分结扎大鼠门脉主干2周后，采用激光多普勒血流计（LDF）测定大鼠胃粘膜血流量（GMBF），观察了垂体后叶素输注前和输注后30min，门脉压力（PVP）的变化；测定了输注垂体后叶素30min后血浆胰高精素的含量。结果显示输注垂体后叶素10minPHG大鼠的GMBF开始降低（P＜0．05），15min显著降低（P＜0．01）；输注垂体后叶素30min后显著降低PHG大鼠PVP（P＜0．01），而血浆胰高糖素无明显变化（P＞0．05）。表明垂体后叶素能有效降低PHG大鼠GMBF，而对血浆胰高糖素无明显影响。

Two weeks after portal vein ligation,The gastric mucosal blood flow(GMBF)was assessed by laser doppler flowmetry,the changes of GMBF and PVP were observed before and 30min after intrayenous vasopressin,plasma glucagon were tested 30min after intravenous vasopressin and saline. The results showed that the GMBF were reduced lomin (P < 0. 05 ) and 15min (P < 0. 01 ) after intravenous vasopvessin, vasopressin administration significantly decreased PVP (P < 0.01 ), had no effect on plasma glucagon(P>0. 05). Vasopressin reduced GMBF of rats with PHG,and had no effect on plasma glucagon.