神经元特异性烯醇化酶在儿童系统性红斑狼疮中的临床意义

目的探讨神经元烯醇化酶（neuron specific enolase，NSE）在儿童系统性红斑狼疮（systemic lupus erythematosus，SLE）患者中的临床意义。方法用电化学发光仪检测36例儿童SLE患者的血清NSE水平。结果SLE组NSE水平（18．8±4．5）ng／ml，显著高于对照组的（9．1±2．5）ng／ml，差异有统计学意义（P〈0．05）。结论SLE患者NSE水平明显升高，NSE有可能作为早期判断狼疮脑病是否存在的敏感指标。

Objective To investigate the clinical significance of neuron - specific cnolase in children with systemic lupus erythematosus. Methods To detected serum NSE level of children （36 cases ） with SLE by Electro - Chemiluminescence finmunoassay（ECLI）. Results SLE group NSE level （ 18.8 ± 4. 5 ） ng/ml was significantly higher than control group （ 9. 1 ± 2. 5） ng/ml, （P 〈 0. 05）. Conclusion The NSE levels of children with SLE was significantly higher, The NSE may be used as a sensitive indicator early to judge whether there was lupus encephalopathy