甘油果糖联合多巴胺、立其丁治疗大面积脑梗死引起的脑水肿的临床研究

Clinical Study of Cerebral Edema Caused by Massive Cerebral Infarction Treatment Together with Glycerol Fructose,Dopamine and Phentolamine

目的探讨治疗大面积脑梗死引起的脑水肿的治疗方案。方法对312例大面积脑梗死病人随机分为治疗组及对照组,治疗结果进行回顾性分析。结果经统计学处理肾功能衰竭的发生情况,治疗组与对照组相比差异有统计学意义(P<0.01);2组疗效情况,治疗组与对照组相比有效率差异有统计学意义(P<0.01),治疗组病程的恶化率及死亡率明显低于对照组。结论甘露醇与甘油果糖联用;早期应用小剂量多巴胺、立其丁;小剂量应用甘露醇,滴速不能过快,疗程不能过长。以上方法能有效防治甘露醇治疗大面积脑梗死引起的急性肾功衰竭,提高大面积脑梗死的总有效率,降低恶化率及死亡率。

Objective To explore the treatment protocols of cerebral edema caused by massive cerebral infarction.Methods 312 cases of massive cerebral infarction were randomly divided into treatment group and control group.Their treatment results were retrospectively analyzed.Result There are statistical significance（P0.01）in the differences between two groups by statistical analysis of the incidence of renal failure.From the aspect of curative effect,there are statistical significance（P0.01）in the different effective rate of two groups.Deterioration rate and mortality of treatment group is significantly lower than that of another group.Conclusion Combined use of mannitol and glycerin fructose;Use small dose of dopamine,phentolamine in early stage;Small dose of mannitol,dripping slow and short course of treatment.The above methods can effectively prevent acute renal failure caused by massive cerebral infarction,enhancing the effective rate of treatment of massive cerebral infarction,reducing deterioration rate and mortality.