梅尼埃病合并甲状腺功能低下症的免疫相关分析

An epidemiological analysis on idiopathic hypothyroidism in patients with Meniere＇s disease

目的评估梅尼埃病患者合并甲状腺机能减退症的免疫相关陆。方法回顾性病例对照研究，比较梅尼埃病fMD）与普通眩晕症之间同期应用甲状腺素补充替代疗法患者的分布情况。2005年2月-2010年5月间收治的以眩晕为主诉的患者1908例，其中50例梅尼埃病患者，符合1996年10月中华医学会耳鼻咽喉科学会全国会议（上海）制定的梅尼埃病诊断依据。对照组50例眩晕症患者，年龄、性别配比对照。结果50例梅尼埃病患者中16例（32％）同期服用甲状腺素治疗甲状腺机能减退症，对照组2例（4％）应用甲状腺素补充替代疗法。x^2检验两组差异有极显著性（P〈0．001）。梅尼埃病患者中位年龄为56岁，小于56岁的26例中有5例（19％）服用甲状腺素，56岁以上（包括56岁）的24例中有11例（46％）服用甲状腺素（P〈0．05）。听力损失严重程度以及单耳或双耳听力损失与MD患者是否伴有甲状腺功能障碍差异无显著性。结论梅尼埃病与特发性甲状腺机能低下症有关，发现甲状腺机能减退症最大的几率是在56岁以上的MD患者中。

Objective To estimate the prevalence of hypothyroidism in a population of patients with Meniere＇s disease（MD）. Methods Retrospective case-control study was carried out to compare the use of thyroid hormone supplements between patients with MD and controls with only dizziness. The 50 patients who met the criteria for MD were identified from a database of 1908 patients with dizziness within over a 5-year period. Results Among the 50 cases, 16（32%）were taking thyroid hormone supplements in contrast to 2（4%） matching significant difference（P〈 0.001 ）.The median age of the patients with MD was 56 years old, and 5（ 19%）of the 26 patients younger than 56 years old were taking thyroid hormone supplements, comparing with 11（46%）of24 patients who were 56 years old or older （P〈 0.05）. There were no statistical significant differences in the severity of hearing loss, pattern of hearing loss, or prevalence of bilateral of hearing loss, between patients with MD who were taking thyroid hormone supplements and patients without MD. Conclusion Meniere＇s disease is associated with idiopathic hypothyroidism. The likelihood of finding hypothyroidism is highest in MD patients older than 56 years.