提高灰黄霉素溶解度的研究

Research to enhance solubility of griseofulvin

灰黄霉素作为一种难溶的抗生素，如何提高其溶解度以利于人体吸收在国外已成为研究热点。本文详细描述了溶解度测定原理，准确测定了灰黄霉素在丙酮中的溶解度并发现采用混合溶剂能提高灰黄霉素的溶解度，弥补了这方面数据在国内外的不足。基于目前国内外灰黄霉素的生产大多采用以丙酮作为溶媒浸取灰黄霉素干菌体的方法，相关基础数据的取得对工业生产有较大的指导意义。

Griseofulvin is a kind of sparely soluble antibiotic in water. Now, it′s a hotspot research work to make it can be absorbed in human′s body by enhancing the solubility. The article discussed the principle of detecting the solubility of griseofulvin in acetone and discovered the solubility of griseofulvin can be improved by using mixed solvent. So far the production of griseofulvin is using acetone to extract the useful ingredient from dried mycelia.