人参果粗多糖的抗衰老作用研究

Antiaging actions of coarse polysaccharide from fruit of ginseng(CPFG)

目的 观察人参果粗多糖（ＣＰＦＧ）的抗衰老作用。方法 ＣＰＦＧ按２００、４００ ｍ ｇ／ｋｇ 给老年大鼠连续灌胃３０ ｄ，测血清ＭＤＡ含量，脑和肝组织脂褐质（Ｌｆ）含量，皮肤和肝组织羟脯氨酸（Ｈｙｐ）含量及血清ＳＯＤ、ＣＡＴ、ＧＳＨ－Ｐｘ 活性。结果 ＣＰＦＧ 两剂量组均能明显降低老年大鼠血清ＭＤＡ 含量及脑和肝组织Ｌｆ含量，明显提高血清ＳＯＤ、ＣＡＴ、ＧＳＨ－Ｐｘ 活性及皮肤Ｈｙｐ 含量。结论 ＣＰＦＧ可能通过改善自由基代谢发挥抗衰老作用。

To observe antiaging actions of CPFG.Methods 200 and 400 mg/kg of CPFG were given to the old rats every day for thirty days. The content of malon dialdehyde(MDA) in serum, the contents of lipofuscin(Lf) in brain and liver, the content of hydrooxyproline(Hyp) in skin and liver and the activity of superoxide dismutase(SOD), catalase(CAT) and glutathione peroxidase(GSH Px) in serum were examined.Results CPFG could decrease significantly the content of MDA in serum and the content of Lf in brain and liver and also increase the activity of SOD, CAT, GSH Px in serum and the content of Hyp in skin of the old rats. Conclusions These results suggest that CPFG has antiaging action with improving metabolism of free radicals.