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DJ-1与肿瘤的关系 被引量：4

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摘要 现已明确,恶性肿瘤是一种基因病,各种原癌基因的激活、异常扩增及抑癌基因的失活最终导致恶性肿瘤的发生和发展.DJ-1基因是日本学者NAGAKUBO等[1]于1997年发现的一种新的丝裂原依赖性癌基因,其编码的DJ-1蛋白能够协同Ras蛋白引起小鼠NIH-3T3细胞的转化.
作者 严金金 舒宽勇 朱其舟
机构地区 江西省妇幼保健院肿瘤科
出处 《广东医学》 CAS CSCD 北大核心 2011年第23期3147-3149,共3页 Guangdong Medical Journal
关键词 DJ-1基因 恶性肿瘤 NIH-3T3细胞 DJ-1蛋白 原癌基因 RAS蛋白 抑癌基因 基因病
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献24

  • 1NAGAKUBO D,TAIRA T,KITAURA H,et al.DJ-1,a novel oncogene which transforms mouse NIH3T3 ceils in cooperation with ras[J].Biol Chem Biophys Res Commun,1997,231(2):509-513.
  • 2MILLER D W,AHMAD R,HAGUE S,et al.L166P mutant DJ-1,causative for recessive Parkinson′s disease,is degraded through the ubiquitin proteasome system[J].Biol Chem,2003,278(38):36588-36595.
  • 3HONBOU K,SUZUKI N N,HORIUEHI M,et al.The crystal structure of DJ-1,a protein related to male fertility and Parkinson′s disease[J].Biol Chem,2003,278(33):31380-31384.
  • 4YOKOTA T,SUGAWARA K,ITO K,et al.Down regulation of DJ-1 enhances cell death by oxidative stress,ER stress,and proteasome inhibition[J].Biochem Biophys Res Commun,2003,312(4):1342-1348.
  • 5MO J S,KIM M Y,ANIL E J,et al.DJ-1 modulates UV-induced oxidative stresssignaling through the suppression of MEKK1 and cell death[J].Cell Death Difer,2008,15(6):1030-1041.
  • 6YUEN H F,CHAN Y P,LAW S,et al.DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma[J].Cancer Epidemiol Biomarkers Prev,2008,17(12):3593-3602.
  • 7KARUNAKARAN S,DIWAKAR L,SAECD U,et al.Activation of apoptosis signal regulating kinase 1(ASK1)and translocation of death-associted protein,Daxx,in substantia nigra pars compacta in a mouse model of Parkinson′s disease:protection by alpha-lipoic acid[J].FASEB J,2007,21(9):2226-2236.
  • 8BRETAUD S,ALLEN C,INGHAM P W,et al.p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson′s diseases[J].J Neurochem,2007,100(6):1626-1635.
  • 9FAN J,REN H,JIN N,et al.DJ-1 decreases Bax expression through repressing p53 transcriptional activity[J].Biol Chem,2008,283(7):4022-4030.
  • 10HOD Y.Differential control of apoptosis by DJ-1 in prostate benign and cancer cells[J].Cell Biochem,2004,92(6):1221-1233.

二级参考文献14

  • 1Hui AM, Makuuchi M. Molecular basis of multistep hepatocarcinogenesis: genetic and epigenetic events. Scand J Gastroenterol, 1999, 34: 737-742.
  • 2Nagakubo D, Taira T, Kit,aura H, et al. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ms. Biochem Biophys Res Commun, 1997, 231: 509-513.
  • 3Kim RH, Peters M, Jang Y, et al. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell, 2005, 7: 263-273.
  • 4Shi W, Zhang X, Pintilie M, et al. Dysregulated PTEN-PKB and negative receptor status in human breast cancer. Int J Cancer, 2003, 104: 195-203.
  • 5Le Naour F, Misek DE, Krause MC, et al. Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin Cancer Res, 2001, 7: 3328-3335.
  • 6MacKeigan JP, Clements CM, Lich JD, et al. Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha. Cancer Res, 2003, 63: 6928-6934.
  • 7van Duijn CM, Dekker MC, Bonifati V, et al. Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. Am J Hum Genet, 2001, 69: 629-634.
  • 8Bonifati V, Rizzu P, van Baren MJ, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science, 2003, 299: 256-259.
  • 9Tao X, Tong L. Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease. J Biol Chem, 2003, 278: 31372-31379.
  • 10Hod Y. Differential control of apoptosis by DJ-1 in prostate benign and cancer cells. J Cell Biochcm, 2004, 92: 1221-1233.

共引文献11

同被引文献30

  • 1谢思明,沈丽佳,殷操,阮萍,姚希.PTEN和FHIT在口腔鳞癌中的表达及意义[J].暨南大学学报（自然科学与医学版）,2005,26(2):237-241. 被引量：6
  • 2祝小林,雷文斌,何小洪,贾涛,苏振忠.DJ-1蛋白在喉鳞状细胞癌与Hep-2细胞系表达[J].中山大学学报（医学科学版）,2007,28(2):142-145. 被引量：5
  • 3Honbou K,Suzuki n N,Horiuehi M,et aI.The crystal structure of DJ-l,a protein related to male fertility and Parkinson's disease[J].Biol Chem, 2003,278(55) : 31380-31384.
  • 4Pardo M,Oarc i a A,Thomas B,et al.The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUCI8 and HMG-I metastasis markers and leads to the identification of PJ-I as a potential serum biomarker [J].int J Cancer,2006,119(5):1014-1022.
  • 5Le Naour F,Misek DE,Krause MC,et aI.Proteomics-based identification of RS/DJ-1 as a novel circulation tumor anti-gene in breast cancer[J]. Clin Cancer i~es, 2001,7(11 ), 3328-3335.
  • 6REVA T, MORROSON S J, CLARKE M F, et al. Stem ceils, cancer, and cancer stem cells[J]. Nature, 2001, 414(6859) : 105 - 111.
  • 7NAOUR F, MISEK D E, KRAUSE M C, et al. Pro- teomics-based identification of RS/DJ-1 as a novel circu- lating tumor antigen in breast cancer [ J ]. Clin Cancer Res, 2001,7(3):3328-3335.
  • 8TAIRA T, TAKAHASHI K, KITAGAWA R, et al. Mo- lecular cloning of human and mouse DJ-1 genes and iden- tification of Spl-dependent activation of the human DJ-1 promoter[J]. Gene, 2001, 263(1 -2) :285 -292.
  • 9BARUA A, EDASSERY S L, BIrlq'ERMAN P, et al. Prevalence of antitumor antibodies in laying hen model of human ovarian cancer[J]. Int J Gynecol Cancer, 2009, 19(4) : 500 -507.
  • 10LIU H, WANG M, LI M, et al. Expression and role of DJ-1 in leukemia [ J ]. Biochem Biophys Res Commun, 2008,375 (3) : 477 - 483.

引证文献4

二级引证文献5

广东医学
2011年 第23期

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