血清PA、ALB及TBA联合检测在肝病诊断中的应用价值

Application value of combined detection of serum PA,ALB and TBA in diagnosis of liver disease

目的探讨血清前清蛋白(PA)、清蛋白(ALB)、总胆汁酸(TBA)联合检测在肝脏疾病诊断中的应用价值。方法对248例肝病患者(肝炎组32例,肝硬化组43例,肝癌组173例)和68例健康体检者(对照组)同时测定血清PA、ALB、TBA等指标水平,比较肝炎组、肝硬化组、肝癌组和对照组各项指标间的差异。结果肝炎组、肝硬化组、肝癌组肝病患者血清PA、ALB水平均显著低于对照组(P<0.01),TBA水平均高于对照组(P<0.05);肝硬化PA、ALB、TBA异常率最高,显著高于肝炎组和肝癌组(P<0.01)。结论联合测定血清PA、ALB、TBA对肝功能损害的早期诊断和预后判断具有重要临床价值。

Objective To explore the application value of combined detection of serum prealbumin（PA）,albumin（ALB） and total bile acid（TBA） in diagnosis of liver disease.Methods Simultaneous detections of serum PA,ALB and TBA were conducted in 248 patients with liver diseases（hepatitis group of 32 patients,liver cirrhosis group of 43 patients and liver cancer group of 173 patients） and 68 healthy people undergoing physical examination.Each indicators in hepatitis,liver cirrhosis,liver cancer and control group were compared.Results Levels of serum PA,ALB were lower（P0.01） and TBA were higher（P0.05） in hepatitis,liver cirrhosis and liver cancer group than those in control group.Serum PA,ALB and TBA in liver cirrhosis group demonstrated the highest rates of abnormality,which were significantly higher than those in hepatitis and liver cancer group（P0.01）.Conclusion Combined detection of serum PA,ALB and TBA has important clinical value in early diagnosis and prognosis judgment of liver dysfunction.