银杏叶提取物对慢性阻塞性肺疾病急性加重期患者氧化应激的影响

Effects of Ginkgo Biloba Eextracts on Oxidative Stress of Patients with Chronic Obstructive Pulmonary Disease at Acute Exacerbation Stage

目的研究银杏叶提取物(GBE)对慢性阻塞性肺疾病加重期患者(AECOPD)血浆8-异向前列腺素(8-iso-PGF2α)、超氧化物歧化酶(SOD)、血气的影响。方法选择健康体检者30例为对照组,AECOPD患者60例(AECOPD组)作为入选病例,并随机分成治疗组(GBE+西医常规治疗)与常规组(西医常规治疗)各30例。治疗组除西医常规治疗外,加GBE注射液20 mL稀释于5%葡萄糖注射液250 mL中静脉滴注,qd,疗程为2周。比较治疗前、后8-iso-PGF2α、SOD、血气分析等临床指标。结果 AECOPD组治疗前和对照组血浆8-iso-PGF2α分别为(158.73±36.78),(37.56±23.45)pg.mL-1(P<0.01);SOD分别为(83.30±7.35)(,101.30±6.90)U.mL-1](P<0.01);治疗组和常规组治疗后血浆8-iso-PGF2α分别为(40.62±7.69)(,96.74±10.24)pg.mL-1(P<0.01),SOD水平分别为(98.20±2.52),(90.80±7.24)U.mL-1(P<0.01)。结论 GBE有助于减轻AECOPD患者氧化应激程度,提高患者抗氧化能力。

Objective To study the effect of Ginkgo biloba extracts（GBE） on plasma 8-iso prostaglandin（8-iso-PGF2α）,superoxide dismutase（SOD） and blood gas of patients with chronic obstructive pulmonary disease at exacerbation（AECOPD） stage. Methods Thirty healthy people as control,60 patients with AECOPD（test group） were selected,the latter were randomly divided into treatment group（GBE ＋ conventional treatment） and control group（conventional treatment）,30 cases in each.The patients in the treatment group were given with 20 mL GBE as infusion diluted in 250 mL glucose solution intravenously,once daily besides conventional treatment for 2 weeks.The clinical indicators as 8-iso-PGF2α,SOD,blood gas before and after treatment were measured and compared. Results The plasma 8-iso-PGF2α in patients with AECOPD and control was（158.73±36.78） and（37.56±23.45） pg·mL-1;SOD was（83.30±7.35） U·mL-1 and（101.30±6.90） U·mL-1,respectively,before treatment.The plasma 8-iso-PGF2αin the treatment group and control after treatment was（40.62±7.69） pg·mL-1 and（96.74±10.24） pg·mL-1,SOD was（98.20±2.52） and（90.80±7.24） U·mL-1,respectively. Conclusion GBE is benefit for ameliorating oxidative stress in patients with AECOPD,and increases antioxidative capacity of patients.