扶正祛邪丹治疗骨髓增生异常综合征的临床及实验研究

Clinical and Experimental Study on the Treatment of Myelodysplastic Syndromes with Fuzheng Quxie Tablet

目的:研究扶正祛邪丹对骨髓增生异常综合征(MDS)的疗效与作用机理。方法:用扶正祛邪丹为主治疗MDS患者33例,观察血象、骨髓象、骨髓病理切片及免疫学的变化;用干细胞培养法观察扶正祛邪丹对BALB/C小鼠骨髓造血干细胞增殖的影响。结果:临床患者基本缓解率2424%,总有效率7272%。实验研究发现扶正祛邪丹对骨髓红系造血干细胞有明显促进作用。结论:扶正祛邪丹对MDS的难治性贫血疗效较好,可能是通过促进红系造血干细胞增殖实现的。

To study the mechanism of Fuzheng Quxie Tablet (FZQXT) in treating myelodysplastic syndromes (MDS). Methods: Thirty three cases of MDS were treated with FZQXT, changes of peripheral blood cells, morphology of bone marrow smear, bone marrow pathology and immunology were monitored before and after treatment. The effects of FZQXT on hematopoietic stem cells of mice were also observed. Results: The remission rate and total effective rate were 24.24% and 72.72% respectively. FZQXT had obvious effect in promoting the proliferation of colony forming unit erythrocytes (CFU E). Conclusion: The beneficial effect of FZQXT in treating refractory anemia might be reached through promoting the proliferation of erythrocytic hematopoietic stem cells.