摘要
流感嗜血杆菌是引起人类呼吸道感染的常见致病菌,尤其在儿童中。近年来,由于抗生素的广泛使用,流感嗜血杆菌对β-内酰胺类抗生素、复方新诺明、四环素、氯霉素、大环内酯类的耐药率不断上升,且存在明显的地区差异。此外,β-内酰胺酶阴性的耐氨苄西林(BLNAR)流感嗜血杆菌报道增加,更表明了抗生素选择压力下复杂的耐药机制。该文就流感嗜血杆菌对常用抗生素的耐药性和耐药机制作一综述。
Haemophilus influenzae is the common pathogenic bacteria of respiratory tract infections in human,particularly,in children.Recently,with the widespread use of antibiotics,resistances to various antibiotics such as β-lactams,trimethoprim-sulfamethoxazole,tetracyclines,chloramphenicol and macrolides become increasingly serious and have distinct differences in different regions.In addition,the growing cases of β-lactmase-negative ampicillin-resistance（BLNAR） show complex resistance mechanism under selecting pressure in haemophilus influenzae.This paper reviews on the antimicrobial resistance and resistance mechanism in haemophilus influenzae.
出处
《安徽医药》
CAS
2011年第12期1471-1474,共4页
Anhui Medical and Pharmaceutical Journal
关键词
流感嗜血杆菌
抗生素
耐药机制
haemophilus nflueniza
antibiotic
resistance mechanism
