156例早孕梅毒驱梅治疗的疗效观察

156 cases of pregnancy outcomes of women infected with syphilis

目的妊娠梅毒经驱梅治疗后的妊娠结局及新生儿梅毒的发病率。方法收集156例妊娠梅毒,分为TRUST滴度≤1∶4组及TRUST滴度≥1∶8组,在经过早期(16周前)及晚期(36周前)进行两次规范治疗后,观察两组孕妇的妊娠结局和新生儿的梅毒发病率。结果 TRUST滴度≤1∶4孕妇足月产89例,早产3例,无流产、死胎或死产,4例TRUST阳性,无先天性梅毒;TRUST滴度≥1∶8孕妇足月产50例,早产13例,12例TRUST阳性,疑似先天性梅毒2例。结论经过正规驱梅治疗,孕妇血清TRUST滴度≤1∶4者,其围产儿预后明显好于TRUST滴度≥1∶8者,孕妇血清TRUST滴度越高,其围产儿预后越差。

Aim To survey the incidence of syphilis of pregnant women who underwent standard treatment twice and incidence of neonate＇s syphilis.Methods 156 cases of the syphilis of pregnant women were collected from Aug 2007 to Aug 2010,all of which were treated with benzathine penicilin 2.4 Mu,IM,once a week for 3 weeks,before 28 gestation weeks and 36 gestation weeks.Results In 92 cases pregnant women＇s Trust titre was lower than 1∶ 4,89 cases had normal delivery,3 cases premature babies,no nature abortion,no intrauterine death,no stillbirth.4 cases of Trust were positive,without congenital syphilis.64 cases pregnant women＇s Trust titre was higher than 1∶ 8.50 cases had normal delivery,13 cases premature babies,1 case intrauterine death.12 cases of Trust were positive,2 cases suspected congenital syphilis.Conclusion After standard treatment,Trust titre of pregnant women is lower than 1∶ 4.Their neonates were better than those Trust titre higher than 1∶ 8.