羧甲纤维素颗粒治疗便秘

Carmellose granules in treating costipation

目的：观察羧甲纤维素对便秘的疗效。方法：１３３ 例便秘病人随机分为２ 组，羧甲纤维素组６８ 例（ 男性３０ 例，女性３８ 例，年龄４０ ａ ±ｓ １１ ａ） ， 每次以２５０ ｍ Ｌ饮水冲饮羧甲纤维素颗粒２ ｇ，ｔｉｄ ， 疗程７ ｄ 。安慰剂组６５ 例（ 男性２７ 例，女性３８ 例，年龄４２ ａ±１２ ａ） 给糊精制剂作平行对照，同时观察排便伴随症状和不良反应。结果：总有效率治疗组和安慰剂组分别为８８ ％ 和３６ ％ （ Ｐ＜ ０ ．０１） ； 起效时间分别为２５ ｈ ±１５ ｈ 和４０ ｈ ±１８ ｈ（ Ｐ＜ ０ ．０５） ； 排便伴随症状发生率分别为１７ ％ 和４８ ％ （ Ｐ＜ ０ ．０１） ； 不良反应率分别为４ ％ 和１２ ％ （ Ｐ＞ ０ ．０５） 。结论：羧甲纤维素为一安全有效的膨胀性泻药。

AIM: To observe the effect of carmellose granules in treating constipation. METHODS: One hundred and thirty_three patients with habitual constipation and bedrid constipation were randomly assigned to two groups: 68 patients (M 30, F 38; age 40 a±s 11 a) were treated with carmellose granules 2 g po tid and 65 patients (M 27, F 38; age 42 a±12 a) received placebo similar to carmellose granules. Both groups were treated for 1 wk. RESULTS: The total effective rate of carmellose granules group (88%) were superior to that of the placebo group (36%, P<0.01). The initial responses and irritant symptoms following defecation in carmellose granules group were 25 h±15 h and 17%,lower than those in placebo group(40 h±18 h,P<0.05; 48 %, P < 0.01). The adverse drug reactions in carmellose granules group was 4% similar to that of placebo group (12%, P>0.05). CONCLUSION: Carmellose granules is a good laxative.