摘要
目的:观察羧甲纤维素对便秘的疗效。方法:133 例便秘病人随机分为2 组,羧甲纤维素组68 例( 男性30 例,女性38 例,年龄40 a ±s 11 a) , 每次以250 m L饮水冲饮羧甲纤维素颗粒2 g,tid , 疗程7 d 。安慰剂组65 例( 男性27 例,女性38 例,年龄42 a±12 a) 给糊精制剂作平行对照,同时观察排便伴随症状和不良反应。结果:总有效率治疗组和安慰剂组分别为88 % 和36 % ( P< 0 .01) ; 起效时间分别为25 h ±15 h 和40 h ±18 h( P< 0 .05) ; 排便伴随症状发生率分别为17 % 和48 % ( P< 0 .01) ; 不良反应率分别为4 % 和12 % ( P> 0 .05) 。结论:羧甲纤维素为一安全有效的膨胀性泻药。
AIM: To observe the effect of carmellose granules in treating constipation. METHODS: One hundred and thirty_three patients with habitual constipation and bedrid constipation were randomly assigned to two groups: 68 patients (M 30, F 38; age 40 a±s 11 a) were treated with carmellose granules 2 g po tid and 65 patients (M 27, F 38; age 42 a±12 a) received placebo similar to carmellose granules. Both groups were treated for 1 wk. RESULTS: The total effective rate of carmellose granules group (88%) were superior to that of the placebo group (36%, P<0.01). The initial responses and irritant symptoms following defecation in carmellose granules group were 25 h±15 h and 17%,lower than those in placebo group(40 h±18 h,P<0.05; 48 %, P < 0.01). The adverse drug reactions in carmellose granules group was 4% similar to that of placebo group (12%, P>0.05). CONCLUSION: Carmellose granules is a good laxative.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1999年第6期343-344,共2页
Chinese Journal of New Drugs and Clinical Remedies