噻氯匹定治疗急性脑梗死

Ticlopidine in treatment of acute cerebral infarction

目的：观察噻氯匹定对急性脑梗死的疗效及对血小板α颗粒膜蛋白（ＣＤ６２Ｐ） 及血小板溶酶体完整膜蛋白（ＣＤ６３） 的影响。方法：２ 组（ 各３０ 例） 均给予一般性治疗（ 甘露醇、川芎嗪、卡托普利及格列齐特） ，噻氯匹定组另予噻氯匹定２５０ ｍｇ ， ｐｏ，ｑｄ ×３０ｄ 。治疗前后做ＣＤ６２Ｐ， ＣＤ６３ 含量检测及疗效评定。结果：急性脑梗死病人ＣＤ６２Ｐ及ＣＤ６３ 含量比正常对照明显增高（ Ｐ＜ ０ ．０１） ， 治疗３０ ｄ 后明显降低（ Ｐ＜０ ．０１） ；噻氯匹定组总有效率（８０ ％ ） 高于对照组（５３ ％ ） 。结论：噻氯匹定能抑制急性脑梗死病人血小板的激活，减少对脑的损害，促进神经功能恢复，可用于治疗急性脑梗死。

AIM: To evaluate the clinical and laboratory effects of ticlopidine on granule membrane protein of platelet (CD 62P , CD 63 ) in treating acute cerebral infarction (ACI). METHODS: Sixty patients with ACI were divided into ticlopidine group and control group. Thirty patients in ticlopidine group were given conventional treatment (mannitol, ligustrazine, captopril, and gliclazide) and ticlopidine 250 mg, po, qd×30 d, another 30 patients in control group were given only conventional treatment. Before and after treatment, the values of CD 62P and CD 63 were detected by flow cytometry and the degree of neurological damage were examined. The value of thirty healthy volunteers were also detected as normal control. RESULTS: The values of CD 62P and CD 63 of patient in 2 groups that were higher than normal control before treatment (P<0.01) were lowered greatly after 30 d's treatment (P<0.01). The lowering rate of CD 62P and CD 63 in ticlopidine group was higher than that in control group (P<0.01). The total response rate of ticlopidine group (80%) was higher than that of control group (53%)(P<0.05). CONCLUSION: Ticlopidine depresses the activation of platelets in ACI patients and reduces the damage to brain by activated platelets and prompts the resurrection of neural function.