西沙必利对功能性消化不良的疗效及对消化道激素的影响

Effects of cisapride on functional dyspepsia and gastroenteric hormones

目的：观察西沙必利对各型功能性消化不良（ＦＤ） 的疗效及研究其作用机制。方法：选择４０ 例ＦＤ 病人（ 男性２４ 例，女性１６ 例；年龄４０ ａ±ｓ ９ ａ） ，其中运动障碍样型２０ 例，溃疡样型１０ 例，反流样型８ 例，未定型２ 例。采用西沙必利５ ～１０ ｍｇ ， ｐｏ，ｔｉｄ 共４ ｗｋ 。观察临床疗效，并于服用前和服药后１ｈ ，测定Ｐ 物质、促胃动素、生长抑素、降钙素基因相关肽。结果：ＦＤ 症状缓解总有效率９５ ％ ，而服药前后对消化道激素（ 除Ｐ 物质外） 无明显变化，副作用轻微。结论：西沙必利主要不是通过胃肠动力激素起作用，而是作用于肠肌间神经丛，消除或缓解ＦＤ的症状。

AIM: To observe the effects of cisapride (Cis) on functional dyspepsia(FD). METHODS: Forty patients diagnosed them 20 with dysdynamic, 10 with ulcer_like, 8 with regurgitative and 2 with non_idiopathic. Cis were administred 5_10 mg, po, tid for 4 wk and clinical effects were recorded. Before and after Cis 10 mg were administered the serum substance P, motilin (Mot), somatostatin (SS), and calcitonin gene_related peptide(CGRP) were detected. RESULTS: Total effective rate of FD was 95%. But Mot, SS, CGRP there were no difference before and after 1 h administration of Cis, substance P was elevated (P<0.05). Side effects were mild. CONCLUSION: Cis plays its role on intermyoenteric nerve plexus and diminishes or remisses the symptoms of FD.