摘要
目的探讨检测病毒性脑炎(VE)患儿血清中可溶性细胞间黏附分子-1(sICAM-1)和可溶性P-选择素的作用。方法应用酶联免疫吸附双抗体夹心法分别检测26例VE患儿急性期、恢复期及20例正常儿童血清中sICAM-1[(372.6±113.6)μg/L]和可溶性P-选择素[(38.2±12.1)μg/L]的水平。结果 VE患儿急性期血清中的sICAM-1和可溶性P-选择素显著高于对照组[(277.4±87.8)μg/L和(19.6±4.2)μg/L],差异有统计学意义(P<0.01),恢复期患儿血清中sICAM-1[(305.2±99.1)μg/L]和可溶性P-选择素[(23.6±8.4)μg/L]与对照组比较差异无统计学意义(P>0.05)。结论 VE患儿sICAM-1和可溶性P-选择素水平与病程密切相关,检测血清sI-CAM-1和可溶性P-选择素有助于判断VE患儿病情轻重和评估预后。
Objective To study the levels of serum soluble intercellular adhersion molecule-1（sICAM-1） and soluble P-selectin（sP-selectin） in patients with viral encephalitis.Methods The sICAM-1 and sP-selectin of the serum were measured by ELISA on 26 patients with viral encephalitis in respectively acute phase,recovery phase and 20 normal children.Results The average serum levels of sICAM-1[（372.6±113.6）μg/L] and sP-selectin[（38.2±12.1）μg/L] were much higher in patients with acute viral encephalitis than that in the control group[（277.4±87.8）μg/L and（19.6±4.2）μg/L]（P0.01）,without significant differences in the convalescent patients[（305.2±99.1）μg/L and（23.6±8.4）μg/L]（P0.05）.Conclusion The results indicate that the average levels of sICAM-1 and sP-selectin are positively correlated with the degree of viral encephalitis.Serum sICAM-1 and sP-selectin will contribute to monitoring the clinical course of viral encephalitis.
出处
《检验医学与临床》
CAS
2011年第23期2850-2851,共2页
Laboratory Medicine and Clinic
