难治性晚期大肠癌加用羟基喜树碱治疗21例疗效及毒性分析

Curative Effect of Hydroxycamptothecine for Refractory Colorectal Carcinoma -A Report of 21 Cases

目的: 观察对含氟脲嘧啶联合化疗方案耐药的难治性大肠癌在加用HCPT 后的联合化疗疗效及毒性变化。方法:晚期大肠癌患者接受5 - FU/CF 治疗2 个周期后未达到PR 及以上疗效者于第3 、4 周期在原方案的基础上加用HCPT 治疗2 个或2 个以上周期。结果:21 例用5 - FU/CF 治疗未达PR 的患者,加用HCPT 后,仍有14 % 的有效率(PR) 。毒副反应无明显增加。结论:对5 - FU 耐药的晚期大肠癌患者在原方案基础上加用HCPT,仍可取得一定疗效,且毒副作用无明显增加。

Aim:To study the curative effect of Hydroxycamptothecine (HCPT)on colorectal cancer which failed to respond to 5-Fu. Methods: Twenty-one late stage colorectal cancer patients were treated initially with 5-Fu/CF for two cycles but no PR was achieved then HCPT was added to the original scheme for 2 or more cycles. Results: 14% of the patients had PR after the supplement of HCPT and the side effects were mild. Conclusion: Curative effect could be achieved in late stage colorectal cancer patients who fialed to 5-Fu treatment when HCPT is added to the original scheme of treatment.