白细胞介素-1受体拮抗剂在糖尿病治疗中的作用
被引量:1
摘要
目前认为糖尿病的发病与机体的炎症过程密切相关,已形成糖尿病的炎症发病学说。作为炎症过程的重要调节因子,细胞因子与糖尿病的关系日益引起重视。白细胞介素-1β(IL-1β)是由巨噬细胞、脂肪细胞和内皮细胞等产生和分泌的。IL-1β独立或介导的炎症过程所引起的β细胞功能损伤,是胰岛β细胞衰竭的重要原因。
出处
《中国临床保健杂志》
CAS
2011年第6期664-666,共3页
Chinese Journal of Clinical Healthcare
参考文献18
-
1Juge-Aubery CE, Somm E, Chicheportiche R, et al. Regulatory Effects of Intedeukin (IL)-1, Interferon-β, and IL- 4 on the Production of IL-1 Receptor Antagonistby Human Adipose Tissue. J Clin Endocrinol Metab [ J ]. 2004,89 (6) :2652-2658.
-
2Slotwinski R, Olszewski WL, Slotkowski M, et al. Can the interleukin-1 receptor antagonist (IL-lra) be a marker of anti-inflammatory response to enteral immunonutrition in malnourished patients after pancreaticoduo denectomy [J]. JOP,2007 ,S(6) :759-769.
-
3Orris F, Pirot P, Naamane N, et al. Induction of nuclear factor-kappa B and its downstream genes by TNF-alpha and IL-1 beta has a pro-apoptotic role in pancreatic beta cells[ J]. Diabetologia,2008,51 (7) : 1213-1225.
-
4Donath MY, Schumann DM, Faulenbach M, et al. Islet inflammation in type 2 diabetes: from metabolic stress to therapy[J]. Diabetes Care,2008,31 supp12:S161-S164.
-
5Koenen TB, Stienstra R, van Tits LIH, et al. Txnip expression associates with hyperglycemia-induced inflammation in human peripheral blood mononuclear cells and adipocytes [ J ]. Diabetologia,2009,52 Supp1:253.
-
6Koenen TB, Stienstra R, van Tits LJ, et al. Hyperglycemia Activates Caspase-1 and TXINP-Mediated IL-113 Transcription in Human Adipose Tissue [ J ]. Diabetes, 2011, 60(2) :517-524.
-
7Boni-Schnetzler M, Boiler S, Debray S, et al. Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I [ J ]. Endocrinology,2009,150 (12) :5218-5229.
-
8Boni-Schnetzler, Thome J, Pamaud G, et al. Increased interleukin( IL)-lbeta messenger ribonucleic acid expression in beta-cells of individuals with type 2 diabetes and regulation of IL-1 beta in human islet by glucose and autostimulation [ J ]. J Clin Endocrinol Metab, 2008, 93 (10) :4065-4074.
-
9Gattorno M,Tassi S, Cart S, et al. Pattern of interleukin-1 beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations [ J ]. Arthritis Rheum, 2007,56 ( 9 ) : 3138-3148.
-
10Lachmann HJ, Kone-Paut I, Kuemmerie-Deschner JB, et al. Use of canakinumab in the cryoplyrin-associated periodic syndrome[ J]. N Eng J Med, 2009,360 (23) :2416- 2425.
二级参考文献10
-
1刘开平,沈国清,丘红梅,李薇,周晓芳,姚纪瑜.血清C—反应蛋白与2型糖尿病及其肾病的关系[J].中国现代医学杂志,2006,16(4):600-601. 被引量:7
-
2GRAVES DT,KAYAL RA.Diabetic complications and dysregulated innate immunity[J].Front Biosci,2008,13:1227-1239.
-
3ABRAHAMIAN H,ENDLER G,EXNER M,et al.Association of low-grade inflammation with nephropathy in type 2 diabetic patients:role of elevated CRP-levels and 2 different gene-polymorphisms of proinflammatory cytokines[J].Exp Clin Endocfinol Diabetes,2007,115(1):38-41.
-
4HUNG J,KNUIMAN MW,DIVITINI ML,et al.Prevalence and risk factor correlates of elevated C-reactive protein in an adult Australian population[J].Am J Cardiol,2008,101(2):193-198.
-
5VERZOLA D,GANDOLFO MT,FERRARIO F,et al.Apoptesis in the kidneys of patients with type II diabetic nephropathy[J].Kidney Int,2007,72(10):1262-1272.
-
6CHURCH LD,COOK GP,MCDERMOTT MF.Primer:inflammasomes and interleukin 1beta in inflammatory disorders[J].Nat Clin Pract Rheurnatol,2008,4(1):34-42.
-
7SLOTWINSKI R,OLSZEWSKI WL,SLOTKOWSKI M,at al.Can the interleukin-1 receptor antagonist (IL-1ra) be a marker of anti-inflammatory response to enteral immunonutrition in malnourished patient,after pancreatieoduodenectomy[J].JOP,2007,8(6):759-769.
-
8SALMENNIEMI U,RUOTSALAINEN E,PIHLAJAM?KI J,et al.Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin,cytokines,and adhesion molecules in subjects with metabolic syndrome[J].Circulation,2004,110(25):3842-3848.
-
9ABRAHAMIAN H,ENDLER G,EXNER M,et al.Association of low-grade inflammation with nephropathy in type 2 diabetic patients:role of elevated CRP-levels and 2 different gene-polymorphisms of proinflammatory cytokines[J].Exp Clin Endocrinol Diabetes,2007,115(1):38-41.
-
10HUTCHINSON PJ,O'CONNELL MT,ROTHWELL N J,et al.Inflammation in human brain injury:intracerebral concentrations of IL-lalpha,IL-lbeta,and their endogenous inhibitor IL-lra[J].J Neurotrauma,2007,24(10):1545-1557.
共引文献9
-
1郑秀霞.血清胱抑素C、纤维蛋白原、C反应蛋白对早期糖尿病肾病的诊断价值[J].中国当代医药,2012,19(3):5-6. 被引量:6
-
2吕秀群,刘得华.复方田参胶囊治疗早期糖尿病肾病疗效观察[J].中医药临床杂志,2012,24(12):1195-1196. 被引量:2
-
3刘光明,黄小兵,谭柏松,张伟坚.2型糖尿病肾病患者血清hs-CRP和CRP检测结果分析[J].现代医药卫生,2013,29(13):1938-1939. 被引量:4
-
4逯惠敏,冯琳琳,程姗姗,蒋红梅.2型糖尿病患者血清血管内皮生长因子和白介素-6水平检测[J].中国现代医学杂志,2013,23(21):35-38. 被引量:4
-
5吴琼皎.2型糖尿病肾病患者血清VEGF、IL-6及TNF-α水平的检测与意义[J].中国医药科学,2014,4(20):136-138. 被引量:10
-
6刘艳秋,高美华,李红林.2型糖尿病患者血清中sP-选择素、sE-选择素、IL-6、IL-18检测的临床意义[J].国际检验医学杂志,2015,36(4):549-550. 被引量:4
-
7刘艳秋,高美华,李红林,解长银,章海飞.糖尿病及糖尿病并发冠心病患者血清sP-selectin、sE-selectin水平变化及意义[J].中国免疫学杂志,2015,31(9):1245-1249. 被引量:35
-
8刘艳秋,解长银,王志伟,李红林,王煜.糖尿病肾病患者血清和肽素与降钙素原水平的变化及意义[J].广东医学,2017,38(6):888-890. 被引量:8
-
9颜建军,李利萍,胡杨,程木子,程玲,张文静,张楠,张丽莎.血清IL-19、VASH-1、NLR在2型糖尿病肾病中的水平及临床意义[J].疑难病杂志,2024,23(9):1090-1093.
同被引文献38
-
1赵秀敏.失血性贫血致脑梗死32例临床分析[J].中国实用神经疾病杂志,2006,9(3):76-77. 被引量:2
-
2Cammarata GA, Weil MH, Castillo C J, et al. Buccal capnometry for quantitating the severity of hemorrhagic shock [ J]. Shock ,2009,31 (2) :207-211.
-
3Condon M, Senthil M, Xu DZ, et al. Intravenous injection of mesenteric lymph produced during hemorrhagic shock decreases RBC deformability in the rat [ J ]. J Trauma, 2011,70 ( 2 ) : 489- 495.
-
4Jiang J, Bahrami S, Leichffried G, et al. Kinetics of endotoxin and tumor necrosis factor appearance in portal and systemic circulation after hemorrhagic shock in rats [ J]. Ann Surg, 1995,221 (1) :100- 106.
-
5Yao YM,Tian HM, Sheng ZY, et al. Inhibitory effects of low-dose polymyxin B on hemorrhage-induced endotoxin/baeterial translocation and cytokine formation in rats [ J]. J Trauma, 1995, 38(6) :924-930.
-
6Bini R, Olivero G, Trombetta A, et al. Effects of dimethyl sulfoxide, pyrrolidine dithioearbamate, and methylprednisolone on nuclear faetor-kappaB and heat shock protein 70 in a rat model of hemorrhagic shock [ J ]. J Trauma ,2008,64 (4) : 1048-1054.
-
7Schtitz C, Stover JF, Thompson H J, et al. Acute, transient hemorrhagic hypotension does not aggravate structural damage or neurologic motor deficits but delays the long-term cognitive recovery following mild to moderate traumatic brain injury [J]. Crit Care Med,2006,34(2) :492-501.
-
8Tsai CF, Yip PK, Chert CC, et al. Cerebral infarction in acute anemia [ J]. J Neuro1,2010,257 ( 12 ) :2044-2051.
-
9Parikh SS, Chung F. Postoperative ddifium in the elderly [ J]. Anesth Analg,1995,80(6) :1223-1232.
-
10Wang P, Li Y, Li J. ttydroxyethyl starch 130/0. 4 prevents the early pulmonary inflammatory response and oxidative stress after hemorrhagic shock and resuscitation in rats [J]. Int Immunopharmaco1,2009,9 (3) :347-353.
-
1王育新,章友康,朱世乐,刘玉春,白千帆,郑欣.白细胞介素-1受体拮抗剂的基因多态性在系统性红斑狼疮患者中的分布[J].中华肾脏病杂志,1998,14(2):118-119.
-
2刘艳,贾玉杰.类风湿性关节炎与白细胞介素-1受体拮抗剂的研究[J].医学综述,2004,10(10):587-588. 被引量:1
-
3王艺霏,王勇,韩超,张清华,吴雨虹.冠心病患者血清IL-1ra和IL-6水平与冠脉病变程度及预后的相关性研究[J].海南医学,2014,25(20):3017-3020. 被引量:9
-
4浦奎,洪涛,高春瑞,胥爱源,赵同兴,胡渝生,李惠敏,郭西延,贾忠伟.白细胞介素-1受体拮抗剂对抗心肌缺血-再灌注性损伤的实验研究[J].解放军医学杂志,1998,23(1):48-49. 被引量:1
-
5梁政,李波,王怀龙,魏燕旋,姚峰.冠状动脉粥样硬化性心脏病与炎性细胞因子水平变化的相关性[J].新乡医学院学报,2015,32(4):344-346. 被引量:5
-
6赵桂荣,何冰,李海潮,宿利,李小玲.白细胞介素-1受体拮抗剂对博莱霉素致大鼠肺纤维化模型的影响[J].北京医科大学学报,1999,31(3):277-279. 被引量:7
-
7李博,叶志中,庄俊汉.白细胞介素-1受体拮抗剂治疗类风湿关节炎的研究及进展[J].中华风湿病学杂志,2004,8(5):310-312. 被引量:1
-
8关天俊,刘志红,陈朝红,胡伟新,姚小丹,唐政,黎磊石.狼疮性肾炎患者致病基因多态性的研究[J].肾脏病与透析肾移植杂志,1997,6(1):3-8. 被引量:6
-
9王瑞晨(编译),胡森(审校).预测脓毒症患者发生器官功能障碍和死亡的一组标记物[J].中国危重病急救医学,2009,21(1):20-20.
-
10徐峰,张洪泉.白细胞介素-1受体拮抗剂拮抗豚鼠哮喘的相关机制[J].中国临床药理学与治疗学,2003,8(1):52-54. 被引量:3