血浆同型半胱氨酸水平与颈动脉粥样硬化患者复发性脑梗死的相关研究

Correlation Between Levels of Plasma Homocysteine and Recurrent Cerebral Infarction in Patients with Carotid Atherosclerosis

目的:探讨血浆同型半胱氨酸(Hcy)水平与颈动脉粥样硬化患者复发性脑梗死的关系。方法:颈动脉粥样硬化患者140例,根据脑梗死次数,分为脑梗死复发组45例,脑梗死初发组47例,对照组48例;检测并比较各组血浆Hcy水平及颈动脉内膜中层厚度(IMT)。结果:颈动脉IMT值与血浆Hcy水平正相关;脑梗死复发组及初发组血浆Hcy水平均显著高于对照组(P<0.01),颈动脉IMT值均高于对照组(P<0.05);脑梗死复发组血浆Hcy水平高于脑梗死初发组(P<0.05),但颈动脉IMT值差异无统计学意义。结论:血浆Hcy水平与颈动脉粥样硬化患者复发性脑梗死可能有关。

Objective. To investigate the correlation between the plasma homocysteine （Hcy） levels and recurrent cerebral infarction in patients with carotid atherosclerosis. Methods. One hundred and forty patients with carotid atherosclerosis were enrolled for the study. Accord- ing to the frequency of cerebral infarction, the patients were divided into recurrent cerebral in- farction group （n=45）, initial cerebral infarction group （n=47） and control group （n=48）. The levels of plasma Hcy and the intima media thick （IMT） of the carotid arteries were measured and compared. Results. The IMT of the carotid arteries was positively correlated with the levels of plasma Hcy. The levels of plasma Hcy in the recurrent cerebral infarction group and the initial cerebral infarction group were significantly higher than that in the control group （P%0.01）. The infarction groups were higher than that in the control group lasma Hcy in the recurrent cerebral infarction group was high- nfarction group （P^0.05）, but the IMT of carotid arteries The level of plasma homocysteine is probably positively asso- ciated with recurrent cerebral infarction.