磁共振弥散加权成像评价肝硬化程度的初步研究

Preliminary study of MR diffusion weighted imaging in evaluating the degree of liver cirrhosis

目的探讨肝脏弥散加权成像表观弥散系数值(apparent diffusion coefficients,ADC)评价肝硬化患者肝功能的临床应用价值。方法对95例受检者行DWI检查,正常对照组35例,肝硬化组60例,其中Child-Pugh分级A级、B级28例,为肝硬化AB组,Child-Pugh分级C级32例,为肝硬化C组。测量所有受检者肝脏ADC值,比较三组间ADC值差异。结果正常对照组肝脏ADC值为(1.28±0.14)×10-3mm2/s,肝硬化AB组和C组ADC值分别为(1.18±0.17)×10-3mm2/s和(0.91±0.34)×10-3mm2/s,肝硬化AB组和正常对照组无统计学差异(P=0.069),肝硬化C组和肝硬化AB组、肝硬化C组和正常对照组比较差异有统计学意义(P=0.000,P=0.000)。结论肝硬化患者肝纤维化程度越重,ADC值越小。ADC值在一定程度上能够反映肝硬化程度。

Objective： To investigate the value of MR diffusion weighted imaging （DWI） in patients with liver cirrhosis. Materials and Methods： Ninety-five cases （35 healthy volunteers and 60 patients with liver cirrhosis） were recruited with their apparent diffusion coefficients （ADC） of liver analyzed. According to liver Child-Pugh classification, 60 patients with liver cirrhosis were classified into group AB （28 cases） and group C （32 cases） with their ADC measured and compared intra-group and with that of the volunteers. Results： The ADC values of the control group, group AB and group C were （1.28±0.14）×10-3 mm2/s, （1.18±0.17）×10-3 mm2/s, and （0.91±0.34）×10-3 mm2/s, respectively. The difference was significant between group C and group AB and group C and control group （P=0.000, P=0.000）, respectively. There was no statistical significance between group AB and control group （P=0.069）. Conclusions： The value of ADC decreased as the aggravation of the hepatic cirrhosis. To some extent, the ADC value may reflect the degree of liver cirrhosis.