神经周浸润在乳腺癌中的意义

The significance of perineural invasion in breast carcinoma

目的：对乳腺浸润性导管癌神经周浸润与肿瘤的大小、肿瘤的组织学分级、肿瘤的TNM分期、淋巴结转移、5年存活率、肿瘤标志物CEA等之间的关系进行探讨。方法：65例乳腺浸润性导管癌组织常规取材制片，HE、Goden-Sweet网染，laminin、CEA、vimentinS-P法免疫标记染色，光镜观察。结果：神经周浸润与肿瘤大小、肿瘤的组织学分级、肿瘤的TNM分期、淋巴结转移率均成正相关；与淋巴管浸润关系密切，与血管浸润无明显关系；与5年存活率有关，即神经周浸润阳性的5年存活率低于神经周浸润阴性。结论：神经周浸润应作为乳腺浸润性导管癌一种重要的预后参数。神经周浸润阳性的病例，其预后较差。

Purpose To study the relation of the perineural Invaslon in breast invasive ductal carcinoma tothe size, histological classification, TNM period, metastases of lymph nodes and 5 years survival rate of the tu-mor. Methods Sixty--five cases of breast invasive ductal carcinoma were stained by HE, Godern-Sweet retic-urlar fibres staining method, Laminin, CEA, vimentin were stained by immuniohistochemical S-P method. Re-sults Postive correlation was found between the perineural invasion and the tumor size, classification, TNMperiod and metastases of lymph nodes. Perineural invasion was relation to 5 years survival rate and lymphvesselesinvasion. But was not relation with blood vesseles invasion. Conclusion Perineural invasion may serve as a veryimportant prognostic predictor in the breast carcinoma. The higher the positive rate of the perineural invasion,the worse the prognosis of the patients.