大肠癌c-erbB-2、EGFR及p21^(ras)蛋白共同表达与肿瘤细胞增殖

Co-expression of c-erbB-2, EGFR and p21^（ras） protein in colorectal carcinoma as related to proliferation of the tumor cell

目的：探讨c-erbB-2、EGFR及p21ras癌基因蛋白共同表达对大肠癌细胞增殖的影响。方法：应用免疫组化ABC法检测c－erbB－2、EGFR及p21ras蛋白在69例大肠癌中的表达情况，同时计数肿瘤细胞PCNA增殖指数。结果：3种癌基因蛋白全部阳性，c－erbB－2和EGFR同时阳性及单独。erbB-2阳性的大肠癌，癌细胞PCNA指数高于3种蛋白全部阴性组（P＜0．05）。结论：c-erbB－2、EGFR和p21ras蛋白共同表达以及c-erbB-2和EGFR共同表达可能对大肠癌细胞的增殖有协同促进作用。

Purpose To study the influence between co-expression of c-erbB-2, EGFR and p21ras protein incolorectal carcinomas and proliferation of the tumor cells. Methods The expression of c-erbB-2, EGFR andp21ras protein were studied by immunohistochemical technique(ABC method) in 69 cases of colorectal carcinoma.Results The index of PCNA in carcinomas of the co-expression of c-erbB-2, EGFR and p21 protein, c-erbB-2co-expression with EGFR or c-erbB-2 expression was higher than that in those without any expression(P <0. 05). Conclusion There are high rate of tumor cell proliferation in the co-expression of c-erbB-2, EGFR andp21ras protein, and the co-expression of c-erbB-2 and EGFR.