带状疱疹患者的血清肌钙蛋白I测定

Detection of serum cardiac troponin I in patients with herpes zoster

血清肌钙蛋白Ｉ（ｃＴｎＩ）是心肌细胞损伤的高度敏感和特异的标志。采用血清肌钙蛋白Ｉ的单 隆抗体ＥＬＩＳＡ法测定５０例带状疱疹２血清肌钙蛋白Ｉ（ｃＴｎＩ）。结果显示：重症带状疱ｃＴｎＩ明显增高（３５．７￣１００μｇ／Ｌ），并有乏力，心悸和心动过速等民损害的临床症状体征：７０．８％的中等病情者ｃＴｎＩ增高（７．６￣４３．０μｇ／Ｌ），但临床上无明显心肌损害的症状、体征；

The serum cardiac troponin I (cTnI) is a highly sensitive and specificmarker for myocardiac. damage. It was detecled in 50 patients with herpes zoster(HZ) by ELISA method. The result showed that in 3 patients with severe type HZ,who had fatigue palpitation and tachycardia, cTnI was obviously increased (35. 7 ~l00ug/L,), in most mediale lype HZ patients who did nor have obvious cardiacsymptoms and signs (17 /24 cases), cTnI was increased(7. 6 ~ 43. oug/L). And in 20 patients with increased cTnl, 3 cases had changes of electrocardiogram(suchas partial ST-T changes and arrhythmia). In 29. 2% (7/24 cases) moderate typeHZ patients and all mild type HZ patients (23 cases) cTnI were within the normalranges (o ~ 7 Ug/L). These results indicate that myocardial cells could1 be involvedand damaged by the varicella-zoster virus in HZ patients. The clinical manifesta-tion usually present subclinical type. In severe type HZ, specially in generalizedtype, the possibility of invasion of myocardium by virus could be increased.