计算机图像分析在轻度皮肤刺激反应评判中的运用研究

Application of computer image analysis in evaluation of mild skin irritation reactions

作者借助Photoshop来分析评判轻度皮肤刺激反应。每个受试区用皮肤分光光度测量仪检测，并在试验前后在设定的条件下摄取图像，临床评估则按ICDRG标准。所有图像用图像分析表在GreyscaleRGB，CMYK和Lab模式下进行。结果在各个光亮度或灰度值同皮肤反应程度呈良好的线性相关（r＜－0.996,p＜0.05）。同样皮肤分光光度测量仪所测L和a值与各种模式的光亮度和RGB模式和R和Lab的a值也是呈很好的线性相关r＞0．990,P＜0.05）。作者认为用Photoshop进行图像分析和皮肤分光光度测量仪同样敏感和科学，不失为一种简便易行的皮肤客观评价法。

The mild skin irritation reaction of acute skin occlusive patch test are analysedwith Photoshop. Every test site was measured by chromameter and the image of this sitewas recorded under designed condition before and after patch. All test sites were visuallyscored according to the ICDRG grading Scale. The images were analysed with histogramunder Greyscale, RGB, CMYK and Lab mode of Photoshop. There was linear correlationbetween the value of luminosity or black of each mode and grading of skin irritation (r = -0. 993, P < 0. 05). There were a good linear relationshop between the L and a valuemeasured by chromameter and the value of luminosity or each color mode and the a valuemeasured by chromameter and the Red value of RGB mode or the a value of Lab mode (r> 0. 990, P < 0. 05). The authors suggest that the image analysed with Photoshop is assensitive and scientific as chromameter measurement. It is one of the easily using andobjective evaluation method for skin.