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依帕司他在糖尿病自主神经病变合并胃溃疡中的应用研究 被引量:1

Applied research of Epalrestat for the treatment of diabetic autonomic neuropathy complicated with gastric ulcer
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摘要 目的观察依帕司他能否促进糖尿病自主神经病变合并胃溃疡患者的溃疡修复,提高溃疡愈合率及愈合质量。方法选取糖尿病自主神经病变合并胃溃疡患者,男34例,女28例。随机分成治疗组32例,对照组30例,对照组采用综合治疗糖尿病自主神经病变及常规治疗胃溃疡的方法,治疗组在对照组治疗方法的基础上加用依帕司他50mg,3次/d,治疗后8周在电子胃镜及组织学水平比较两组患者溃疡愈合情况及组织学溃疡愈合质量。结果治疗组溃疡愈合率及愈合质量明显高于对照组,差异有统计学意义(P<0.01)。结论依帕司他可以明显促进糖尿病自主神经病变合并胃溃疡患者的溃疡修复,提高溃疡愈合率及愈合质量,可能与依帕司他改善或减缓糖尿病自主神经病变有关。 Objective To observe whether Epalrestat could promote the ulcer restoration for patients with diabetic autonomic neuropathy complicated with gastric ulcer,increase ulcer healing rate and healing quality.Methods Patients with diabetic autonomic neuropathy complicated with gastric ulcer were selected,34 males and 28 females,they were randomly divided into 32 cases in therapy group and 30 cases in control group.For patients in control group they were treated with combined modality therapy for diabetic autonomic neuropathy and regular therapy method for gastric ulcer,for patients in therapy group,the combined modality therapy method was the same as that in control group,moreover,Epalrestat of 50 mg tid was applied.8 weeks after treatment,ulcer healing condition and quality were compared at electronic gastroscope and histology levels.Results Gastric ulcer healing rate and healing quality in therapy group were significantly higher than those in control group(P0.01).Conclusion Epalrestat could obviously promote the gastric ulcer restoration,increase healing rate and healing quality,the reason is probably that Epalrestat could improve or relieve diabetic autonomic neuropathy.
出处 《中国实用医药》 2011年第31期19-20,共2页 China Practical Medicine
关键词 依帕司他 糖尿病自主神经病变 胃溃疡 愈合质量 Epalrestat Diabetic autonomic neuropathy Gastric ulcer Healing quality
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