CPE和CE方案治疗小细胞肺癌的疗效比较

Comparison between carboplatin and cisplatin plus etoposide and carboplatin plus etoposide in the treatment of small cell lung cancer

目的 评价CPE(卡铂、顺铂、足叶乙甙)和CE(卡铂、足叶乙甙)方案治疗小细胞肺癌(SCLC)的疗效和毒性。方法 应用CPE和CE方案治疗32例SCLC患者,每组16例,CPE组和CE组中的复治病例分别为10例和7例。结果 CPE组和CE组的有效率分别为81.3%(13/16)和87.5%(14/16)(P>0.05)。CPE组与CE组中的复治病例有效率分别为60%(6/10)和42.9%(3/7)(P<0.05)。CPE组与CE组的骨髓抑制率分别为71.9%和93.8%(P<0.05)。两组间其它毒性反应差异无显著性(P>0.05)。结论 CPE方案治疗SCLC的疗效与CE方案相近,但CPE的骨髓抑制明显较CE轻;CPE对复治病例的疗效优于CE。

Objective To evaluate the effect and toxicity of combination chemotherapy with carboplatin and cisplatin plus etoposide (CPE regimen) and carboplatin plus etoposide (CE regimen) in the treatment of small cell lung cancer(SCLC). Methods Thirty two patients with SCLC were treated with CPE and CE regimens, and each regimen had 16 cases respectively. There were 10 retreated cases in CPE group and 7 retreated cases in CE group. Results The total response rate (CR+PR) was 81.3%(13/16) in CPE group, and 87.5%(14/16) in CE group (P>0.05) respectively. The response rate of the retreated cases in CPE group was 60%(6/10), and 42.9%(3/7) in CE group (P< 0.05 ). The bone marrow suppression rate was 71.9% in CPE group and 93.8% in CE group (P<0.05). There were no significant differences between other toxicity in both groups (P>0.05). Conclusion The therapeutic effect of CPE regimen in SCLC is similar to that of CE regimen, but the bone marrow suppression rate of CPE regimen is less severe than that of CE regimen. The therapeutic effect of CPE regimen is better than that of CE regimen for the retreated cases.