再生障碍性贫血患者hepcidin检测及意义

Detection and clinical significance of hepcidin in patients with aplastic anemia

目的探讨再生障碍性贫血(AA)患者血清hepcidin的表达及其与血清铁蛋白(SF)间的关系。方法用ELISA、放射免疫法测定45例AA患者(AA组)血清中的hepcidin及SF水平,并选择60例正常体检者作为对照(C组)。结果 AA组hepcidin和SF高于C组[(237.09±44.77)ng/ml vs.(137.12±40.19)ng/ml和(140.78±42.14)μg/L vs.(77.70±16.83)μg/L](P<0.01);AA组hepcidin和SF水平呈正相关(r=0.982,P<0.01)。输血>3次的AA患者hepcidin和SF高于输血≤3次者[(245.17±40.09)ng/ml vs.(204.84±25.34)ng/ml和(216.55±55.97)μg/L vs.(156.33±43.64)μg/L](P<0.01)。结论 AA患者hepcidin较正常人显著增高,且与输血次数显著相关。

Objective To study the expression of hepcidin and its relationship with serum ferritin（SF） in the patients with aplastic anemia（AA）.Methods ELISA and radioimmunoassay were used to measure serum hepcidin and SF in 45 AA patients（group AA） and 60 normal controls（group C）.Results Serum hepcidin and SF were were significantly higher in group AA than those in group C[（237.09±44.77） ng/ml vs.（137.12±40.19） ng/ml and（140.78±42.14） μg/L vs.（77.70±16.83） μg/L]（P0.01）,which in group AA were higher in the patients receiving blood transfusion three times than those with blood transfusion ≤three times[（245.17±40.09） ng/ml vs.（204.84±25.34） ng/ml and（216.55±55.97） μg/L vs.（156.33±43.64） μg/L]（P0.01）.Conclusion Hepcidin expression is higher in AA patients,which is remarkably related to the frequency of blood transfusion.