联合检测CA125、CA153、CEA、NSE和SF鉴别结核性与癌性积液

Defferencial diagnosis of cancer pleural effusions from tuberculosis thoracic fluid by combined detection of CA125,CA153,CEA,NSE and SF

目的评价糖类抗原(CA125、CA153)、癌胚抗原(CEA)、神经元烯醇化酶(NSE)和铁蛋白(SF)检测在结核性及癌性积液鉴别诊断中的价值。方法选择结核性胸腔积液患者96例,癌性胸腔积液患者54例,采用化学发光免疫法检测胸水及血清中的CA125、CA153、CEA、NSE和SF。结果癌性积液及其患者血清的CA125、CA153、CEA、NSE和SF含量均明显高于结核性积液者(P<0.05)。单一CEA检测的肿瘤检验敏感性低;而与CA153、CEA、NSE、SF联合检测明显提高了敏感性。结论应用多种肿瘤标志物的联合检测能提高癌性积液诊断的敏感性。

Objective To study the value of defferencial diagnosis of cancer pleural effusions（PE） from tuberculosis PE by combined detections of CA125,CA153,CEA,NSE and SF.MethodsThe contents of CA125,CA153,CEA,NSE and SF in PE and serum were examined with chemiluminescence immunoassay in 96 patients with tuberculous PE（group T） and 54 cases with cancer PE（group C）.Results The contents of CA125,CA153,CEA,NSE and SF in PE and serum were significantly higher in group C than those in group T（P0.05）.The sensitivity of tumor diagnosis of PE was lower based on a single tumor marker CEA detection,which was increased by combined detections of the above five tumor markers.Conclusion Combined detections of CA125,CA153,CEA,NSE and SF in PE and serum can improve the sensitivity in diagnosis of cancer PE.