原发性肝癌介入治疗的临床疗效评价

Clinical evaluation of interventional treatment for liver cirrhosis

目的:评价不同类型原发性肝癌介入治疗的临床疗效。方法:回顾性分析78例经中国抗癌协会肝癌委员会标准确诊的原发性肝癌患者的临床资料,对其中60例资料完整者进行临床疗效评价。60例原发性肝癌患者中,无门脉主干瘤栓56例,有门脉主干瘤栓4例;富血供肿瘤50例,中等血供者10例。肿瘤栓塞范围>80%6例;50-79%43例;<50%11例。对60例患者平均随访了2个月至53个月(中位生存时间)。结果:术前、术后AST和ALT的变化率各CT分级之间差异有统计学意义;用生存分析法进行多因素分析Cox回归,发现碘油沉积率和CT分级与生存时间关系最密切,且CT分级Ⅰ级与Ⅳ级间差异显著(P<0.05)。结论:应用介入治疗原发性肝癌可获得满意的临床疗效,碘油沉积率、肝硬化CT分级与临床疗效关系最密切。

Objective：To evaluate the clinical effect of transcatheter arterial chemoembolization for primary hepatocellular carcinoma.Methods： The clinical data were retrospectively analyzed in 78 patients with primary hepatocellular carcinoma confirmed by the standard that laid down by Professional Committee of China＇s anti-cancer.Among the 60 patients of primary hepatocellular carcinoma,tumor embolus in portalvein was found in 4 cases,that was not found in 56 cases;tumor with plenty blood in 50 cases,that with moderate blood in 10 cases.Results： Difference that rate of AST,ALT and CT classify between preoperative and after surgery had statistical significance;survive time had the most intimate with deposition rate of iodipin and CT classify confirmed by survival analysis method and CT classify between Ⅰ grade and Ⅳ grade had significant difference（P〈0.05）.Conclusion：Primary hepatocellular carcinoma treated by interventional therapy gained satisfy clinical effect.Deposition rate of iodipin and CT classify had the most closeness with clinical effect.