摘要
目的：探讨7-氯苄基四氢巴马汀抗心律失常的作用机制。方法：用离休豚鼠心乳头肌标本，观察7－Chlor－BTHP对其生理特性的影响。结果：30μmol．L－17－Chlor－BTHP能增强豚鼠心乳头肌的收缩力，±dT／dtmax也明显增加，明显延长功能性不应期，50μmol．L－17－Chlor-BTHP显著抑制肾上腺素诱发自律性的作用，同时降低兴奋性。结论：7—Chlor—BTHP抗心律失常作用可能与降低自律性、延长功能性不应期有关。
To study the mechanism of antiarrhythemic effect of 7 -chlor- BTHP. Methods The influence of 7 -chlor - BTHP on some physiological properties of isolatedguinea pig papillary muscle were observed. Results 30mol L-1 7-chlor-BTHP increased contractility and ±dT/dtmax, markedly prolonged the functional refractory period (FRP), while50μmol. L-l 7-chlor-BTHP inhibited adrenaline-induced automaticity, and decreased theexcitability of isolated guinea pig papillaly muscle. Conclusion The antiarrhythemic action of 7 chlor - BTHP is related to prolonging the refractory Period and decreasing the automaticity.
出处
《咸宁医学院学报》
1999年第4期224-226,共3页
Journal of Xianning Medical College
关键词
心律失常
豚鼠
心乳头肌
7-Chlor-BTHP
7-chlor-benzyltetrahydropalmatine (7-chlor-BTHP)
Guinea pig papillary muscle
Contractility
Automaticity
Functional refractory Period
Excitability
