支气管肺炎患儿治疗前后血清IGF-Ⅱ、IL-6、IL-8和TNF-α检测的临床意义

Clinical Significance of Determination of Changes of Serum IGF-Ⅱ,IL-6,IL-8,TNF-α Levels After Treatment in Children with Bronchopneamonia

目的:探讨支气管肺炎患儿治疗前后血清IGF-Ⅱ、IL-6、IL-8和TNF-α的变化及其临床意义。方法:应用放射免疫分析对33例支气管肺炎患儿进行了治疗前后血清IGF-Ⅱ、IL-6、IL-8和TNF-α检测,并与35名正常健康儿作比较。结果:支气管肺炎患儿在治疗前血清IGF-Ⅱ、IL-6、IL-8和TNF-α水平显著地高于正常儿组(P<0.01)。结论:IGF-Ⅱ、IL-6、IL-8和TNF-α以不同的方式参与了患儿的发病,其水平的检测对了解病情、指导治疗具有重要的临床价值。

Objective To explore the clinical significance of changes of serum IGF-Ⅱ,IL-6,IL-8 and TNF-α levels after treatment in children with bronchopneamonia.Methods Serum IGF-Ⅱ,IL-6,IL-8 and TNF-α levels with RIA were detected both before and after treatment in 33 patients with children bronchopneumonia as well as in 35 controls.Results Before treatment,serum IGF-Ⅱ,IL-6,IL-8 and TNF-α levels were significantly higher in the patients than those in the controls（P0.01）.2 weekes after treatment the levels were not significantly defferent from those in the controls（P0.05）.Conclusions Serum IGF-Ⅱ,IL-6,IL-8 and TNF-α could take part in the pathogenesis of children bronchopneumonia in various ways and determination of these levels was clinically important.